How visual stimuli activate dopaminergic neurons at short latency
How visual stimuli activate dopaminergic neurons at short latency
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DOI：
10.1126/science.1107026
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发表时间：
2005-03-04
期刊：
影响因子：
56.9
通讯作者：
Redgrave, P
中科院分区：
文献类型：
--
作者：
Dommett, E;Coizet, W;Redgrave, P
意外的，生物学上显著的刺激引起中脑多巴胺能（DA）神经元的短潜伏期，阶段性反应。虽然这个信号对于强化学习很重要，但它传达给前脑目标结构的信息仍然不确定。解码相位DA信号的一种方法是确定DA神经元的感觉输入的感知特性。在麻醉大鼠的上级丘局部去抑制后，DA神经元成为视觉反应，而视觉皮层的去抑制是无效的。作为视觉传入的主要来源，有限的处理能力的丘可能会限制视觉信息内容的相位DA反应。
Unexpected, biologically salient stimuli elicit a short-latency, phasic response in midbrain dopaminergic (DA) neurons. Although this signal is, important for reinforcement learning the information it conveys to forebrain target structures remains uncertain. One way to decode the phasic DA signal would be to determine the perceptual properties of sensory inputs to DA neurons. After local disinhibition of the superior colliculus in anesthetized rats, DA neurons became visually responsive, whereas disinhibition of the visual cortex was ineffective. As the primary source of visual afferents, the limited processing capacities of the colliculus may constrain the visual information content of phasic DA responses.