Dipeptide-catalyzed direct asymmetric aldol reactions in the presence of water
Dipeptide-catalyzed direct asymmetric aldol reactions in the presence of water
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DOI：
10.1016/j.tet.2007.05.077
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发表时间：
2007-08-13
期刊：
影响因子：
2.1
通讯作者：
Li, Runtao
中科院分区：
文献类型：
--
作者：
Lei, Meng;Shi, Lanxiang;Li, Runtao
已经发现并开发了基于L-脯氨酸的二肽作为未修饰的酮与各种醛（包括芳族、脂族、杂芳族和不饱和醛）在0 ℃下在水存在下的直接不对称羟醛缩合反应的有效催化剂。该方法和最佳反应条件使相应的羟醛产物具有较高的产率（高达94%）和良好的对映选择性（高达97%ee）。(C)2007爱思唯尔有限公司版权所有。
The L-proline-based dipeptide has been discovered and developed as an efficient catalyst for the direct asymmetric aldol reactions of unmodified ketones with various aldehydes including aromatic, aliphatic, heteroaromatic, and unsaturated aldehydes in the presence of water at 0 degrees C. The resulted methodology and optimal conditions led to the corresponding aldol products with high yields (up to 94%) and good enantioselectivities (up to 97% ee). (C) 2007 Elsevier Ltd. All rights reserved.