RENAL TRANSPLANT ELASTICITY ULTRASOUND IMAGING: CORRELATION BETWEEN NORMALIZED STRAIN AND RENAL CORTICAL FIBROSIS
RENAL TRANSPLANT ELASTICITY ULTRASOUND IMAGING: CORRELATION BETWEEN NORMALIZED STRAIN AND RENAL CORTICAL FIBROSIS
复制标题
DOI：
10.1016/j.ultrasmedbio.2013.04.007
复制
发表时间：
2013-09-01
影响因子：
2.9
通讯作者：
Min, Robert
中科院分区：
文献类型：
--
作者：
Gao, Jing;Weitzel, William;Min, Robert
移植后，在一个变化很大的时间过程中，随着间质纤维化的发展和肾功能的下降，移植肾的皮质变得更加僵硬。弹性超声成像 (EUI) 已用于评估因病理损伤而导致硬度变化的组织的生物力学特性。我们使用标准化超声应变程序测量准静态变形，前瞻性地评估了肾移植同种异体移植患者的肾皮质硬度，这与肾皮质纤维化的程度相关。为了确定皮质应变，我们使用 2D 斑点跟踪软件（EchoInsight，Epsilon Imaging，安娜堡，密歇根州，美国）对存储的超声回路进行离线分析，捕获使用扫描传感器施加的压力产生的肾皮质及其邻近软组织的变形。标准化应变定义为肾皮质的平均发展应变除以从腹壁到骨盆肌肉的软组织中测量的总体平均应变。使用肾皮质纤维化的班夫评分标准作为金标准，我们将 20 个肾移植同种异体移植物活检组织样本分为两组：第 1 组（n = 10）患有轻度（
After transplantation, over a widely variable time course, the cortex of the transplanted kidney becomes stiffer as interstitial fibrosis develops and renal function declines. Elasticity ultrasound imaging (EUI) has been used to assess biomechanical properties of tissue that change in hardness as a result of pathologic damage. We prospectively assessed the hardness of the renal cortex in renal transplant allograft patients using a normalized ultrasound strain procedure measuring quasi-static deformation, which was correlated with the grade of renal cortical fibrosis. To determine cortical strain, we used 2-D speckle-tracking software (EchoInsight, Epsilon Imaging, Ann Arbor, MI, USA) to perform offline analysis of stored ultrasound loops capturing deformation of renal cortex and its adjacent soft tissue produced by pressure applied using the scanning transducer. Normalized strain is defined as the mean developed strain in the renal cortex divided by the overall mean strain measured in the soft tissues from the abdominal wall to pelvic muscles. Using the Banff scoring criteria for renal cortical fibrosis as the gold standard, we classified 20 renal transplant allograft biopsy tissue samples into two groups: group 1 (n = 10) with mild (