Ciliary neurotrophic factor null mutation and schizophrenia in a Swedish population.
Ciliary neurotrophic factor null mutation and schizophrenia in a Swedish population.
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瑞典人群中的睫状神经营养因子无效突变和精神分裂症。
DOI：
10.1097/00041444-199722000-00004
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Riederer,P
中科院分区：
文献类型：
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作者：
Thome,J;Jonsson,E;Foley,P;Harsanyi,A;Sedvall,G;Riederer,P
根据发育不良假说，神经营养因子系统是一个重要的区域，可能在遗传和神经化学方面参与了精神分裂症精神病的发病机制。对精神分裂症精神病患者和对照组进行了睫状神经营养因子基因零突变的基因分型。精神分裂症患者和对照组的等位基因和基因分布无显著差异。然而，这与精神病家族史呈负相关。因此，不能排除该基因变异代表了特定精神分裂症亚型的易感性标记。开发基于生物学标准的有效诊断工具对精神分裂症的研究至关重要；与目前归类为精神分裂症的异质疾病组相比，更多同质的亚组更有可能代表不同的病原学实体。
According to the maldevelopmental hypothesis, the neurotrophic factor system represents an important area which might be genetically and neurochemically involved in the etiopathogenesis of schizophrenic psychoses. Patients suffering from schizophrenic psychoses and control persons were genotyped for a null mutation of the ciliary neurotrophic factor gene. There were no significant differences in the allelic and genotypic distributions in the total schizophrenic and control samples. However, there was a negative association with a family history of psychosis. Thus, it cannot be excluded that this genetic variant represents a vulnerability marker for specific schizophrenic subtypes. The development of valid diagnostic instruments based on biological criteria is crucial for schizophrenia research; more homogenous subgroups are more likely to represent distinct nosological entities than the heterogenous group of diseases presently categorized as schizophrenia.