Effects of Exercise on sRAGE Levels and Cardiometabolic Risk Factors in Patients with Type 2 Diabetes: A Randomized Controlled Trial
Effects of Exercise on sRAGE Levels and Cardiometabolic Risk Factors in Patients with Type 2 Diabetes: A Randomized Controlled Trial
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DOI：
10.1210/jc.2012-1951
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发表时间：
2012-10-01
影响因子：
5.8
通讯作者：
Min, Kyung Wan
中科院分区：
文献类型：
--
作者：
Choi, Kyung Mook;Han, Kyung Ah;Min, Kyung Wan
内容：晚期糖基化终末产物（sCRP）的可溶性受体水平低与2型糖尿病（T2 DM）患者的全身炎症和血管并发症有关。目的：我们研究了运动对sCRP的影响及其与T2 DM患者的多种心脏代谢危险因素和动脉粥样硬化指标的相关性。设计、设置和参与者：将75例2型糖尿病患者随机分为对照组和有氧运动组（中等强度60分钟，每周5次，持续12周）。主要结果指标：我们评估了sweep，能量消耗，膳食能量摄入，心肺功能，炎症标志物，内脏脂肪面积，脉搏波速度，结果：基线胰岛素浓度与年龄、糖化血红蛋白、血糖、甘油三酯和高密度脂蛋白胆固醇水平独立相关（R-2 = 0.244）。经过12周的运动训练后，运动组的体重、腰围、血压、糖化血红蛋白、载脂蛋白B和游离脂肪酸水平均显著降低。与此同时，心肺适能评估无氧阈值的摄氧量得到改善，身体脂肪百分比和内脏脂肪面积显着下降，在运动组，虽然脉搏波速度和流量介导的扩张没有改变。此外，运动组的血清肌酐水平升高，超敏C反应蛋白水平降低，而对照组则没有。结论：有氧运动沿着2型糖尿病患者血清sRAGE水平的升高，各种心血管代谢危险因素的改善。（临床内分泌代谢杂志97：3751-3758，2012）
Context: Low levels of soluble receptor for advanced glycation end-products (sRAGE) have been linked to systemic inflammation and vascular complications in patients with type 2 diabetes mellitus (T2DM).Objective: We examined the effects of exercise on sRAGE and its association with diverse cardiometabolic risk factors and indicators of atherosclerosis in patients with T2DM.Design, Setting, and Participants: Seventy-five patients with T2DM were randomized into a control group and an aerobic exercise group (60 min at moderate intensity, five times/wk for 12 wk).Main Outcome Measures: We evaluated sRAGE, energy expenditure, dietary energy intake, cardiorespiratory fitness, inflammatory markers, visceral fat area, pulse-wave velocity, and flow-mediated dilatation.Results: Baseline sRAGE concentrations were independently associated with age, glycated hemoglobin, glucose, triglyceride, and high-density lipoprotein cholesterol levels (R-2 = 0.244). After 12 wk of exercise training, the exercise group showed significantly decreased body weight, waist circumference, blood pressure, glycated hemoglobin, apolipoprotein B, and free fatty acid levels. Concurrently, cardiorespiratory fitness assessed by oxygen uptake at anaerobic threshold was improved, and body fat percentage and visceral fat area were significantly decreased in the exercise group, although pulse-wave velocity and flow-mediated dilatation were not changed. Furthermore, sRAGE levels were increased and high-sensitivity C-reactive protein levels were decreased in the exercise group but not in the control group. PercentchangeofsRAGElevelwasnegatively correlated with that of high-sensitivity C-reactive protein during the study period (r = -0.27; P = 0.019).Conclusions: Aerobic exercise increases sRAGE levels along with improvement of various cardiometabolic risk factors in patients with T2DM. (J Clin Endocrinol Metab 97: 3751-3758, 2012)