Treatment of atherosclerosis by macrophage-biomimetic nanoparticles via targeted pharmacotherapy and sequestration of proinflammatory cytokines
Treatment of atherosclerosis by macrophage-biomimetic nanoparticles via targeted pharmacotherapy and sequestration of proinflammatory cytokines
复制标题
巨噬细胞仿生纳米颗粒通过靶向药物疗法和促炎细胞因子的隔离治疗动脉粥样硬化
DOI：
10.1038/s41467-020-16439-7
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发表时间：
2020-05-26
影响因子：
16.6
通讯作者：
Wang, Ruibing
中科院分区：
文献类型：
--
作者：
Gao, Cheng;Huang, Qiaoxian;Wang, Ruibing
血管疾病仍然是死亡和残疾的主要原因，其病因通常涉及动脉粥样硬化。目前通过药物疗法治疗动脉粥样硬化的疗效有限。在这里，我们报道了一种源自巨噬细胞膜包被的 ROS 响应纳米颗粒 (NP) 的仿生药物递送系统。巨噬细胞膜不仅避免了 NPs 从网状内皮系统中的清除，而且还将 NPs 引导至炎症组织，其中 NPs 的 ROS 响应性使得特定的有效负载释放成为可能。此外，巨噬细胞膜隔离促炎细胞因子以抑制局部炎症。药物治疗和这种仿生药物递送系统隔离炎症细胞因子的协同作用可提高动脉粥样硬化的治疗效果。作为治疗动脉粥样硬化的基于活细胞的药物递送系统，与内化ROS响应性纳米颗粒的巨噬细胞相比，表明细胞膜包被的药物递送方法可能比活细胞方法更适合治疗炎症性疾病。
Vascular disease remains the leading cause of death and disability, the etiology of which often involves atherosclerosis. The current treatment of atherosclerosis by pharmacotherapy has limited therapeutic efficacy. Here we report a biomimetic drug delivery system derived from macrophage membrane coated ROS-responsive nanoparticles (NPs). The macrophage membrane not only avoids the clearance of NPs from the reticuloendothelial system, but also leads NPs to the inflammatory tissues, where the ROS-responsiveness of NPs enables specific payload release. Moreover, the macrophage membrane sequesters proinflammatory cytokines to suppress local inflammation. The synergistic effects of pharmacotherapy and inflammatory cytokines sequestration from such a biomimetic drug delivery system lead to improved therapeutic efficacy in atherosclerosis. Comparison to macrophage internalized with ROS-responsive NPs, as a live-cell based drug delivery system for treatment of atherosclerosis, suggests that cell membrane coated drug delivery approach is likely more suitable for dealing with an inflammatory disease than the live-cell approach.