CONGENITAL-MALFORMATIONS IN TWINS IN ENGLAND AND WALES
CONGENITAL-MALFORMATIONS IN TWINS IN ENGLAND AND WALES
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DOI：
10.1136/jech.45.1.43
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发表时间：
1991-03-01
影响因子：
6.3
通讯作者：
WALE, CJ
中科院分区：
文献类型：
--
作者：
DOYLE, PE;BERAL, V;WALE, CJ
研究目的-目的是比较双胞胎与单胞胎的先天畸形率。设计-这项研究是使用人口普查办公室和调查的先天畸形通知计划的数据分析单胞胎和双胞胎的畸形率。设置-这是英格兰和威尔士1979-1980年和1982- 1985年的全国出生调查。参与者-数据包括370万单胎分娩中95510例报告的畸形，76000双胎分娩中1925例报告的畸形。测量和主要结果-双胎畸形比率以母亲年龄特异性单胎率为标准计算。 与单胎生育相比，双胞胎报告的性别不确定和假两性畸形、无脑畸形、动脉导管未闭、外生畸胎、脑积水、脐血管异常、大肠或肛门闭锁或狭窄以及气管食管瘘、闭锁或狭窄的频率明显更高。 双胞胎也有显着的缺陷，多指和并指;先天性髋关节脱位;异常的舌头，鳃裂和耳窦;肛门后酒窝;和Down's syndrome. Conclusions-几个主要畸形显着更常见于双胞胎比单胞胎。 过度的性别不确定和假两性畸形以前没有描述过，可能类似于牛的自由马丁症。 大多数双胞胎中不太常见的情况都是轻微的，报告的缺陷可能是由于对双胞胎中不太严重的情况的认识不足。 唐氏综合症是个例外，这种缺陷很可能是真实的。
Study objective-The aim was to compare congenital malformation rates in twin births with those in singleton births.Design-The study was an analysis of malformation rates in singleton and twin births using data from the Office of Population Censuses and Survey's Congenital Malformation Notification Scheme.Setting-This was a national survey of births in England and Wales in 1979-1980 and 1982-1985.Participants-The data comprised 95 510 reported malformations in 3.7 million singleton births, and 1925 reported malformations in 76 000 twin births.Measurements and main results-Twin malformation ratios were calculated using maternal age specific singleton rates as standard. In comparison with singleton births, twins have significantly higher reported frequencies of indeterminate sex and pseudohermaphroditism; anencephaly; patent ductus arteriosis; exomphalos; hydrocephalus; anomalies of the umbilical vessels; atresia or stenosis of the large intestine or anus; and tracheo-oesophageal fistula, atresia or stenosis. Twins also have significant reported deficits of polydactyly and syndactyly; congenital dislocation of the hip; anomalies of the tongue, branchial cleft and auricular sinus; post-anal dimple; and Down's syndrome.Conclusions-Several major malformations were significantly more common in twins than in singletons. The excess of indeterminate sex and pseudohermaphroditism has not been described before and may be analogous to freemartinism in cattle. Most of the conditions less common in twins are minor, and the reported deficits may be due to underascertainment of the less serious conditions in twins. Down's syndrome is an exception, and the deficit may well be real.