Anticancer roles of let-7f-1-3p in non-small cell lung cancer via direct targeting of integrin β1.
Anticancer roles of let-7f-1-3p in non-small cell lung cancer via direct targeting of integrin β1.
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let-7f-1-3p 通过直接靶向整合素 β1 在非小细胞肺癌中的抗癌作用
DOI：
10.3892/etm.2021.10740
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发表时间：
2021-11
影响因子：
2.7
通讯作者：
Li Y
中科院分区：
文献类型：
--
作者：
Yang Y;Liu Y;Xie N;Shao L;Sun H;Wei Y;Sun Y;Wang P;Yan Y;Xie S;Li Y
肺癌是最常见的癌症类型之一，全世界死亡率最高。MicroRNA在抗癌药物的化疗效果中发挥着重要作用。本研究采用逆转录-定量PCR、Western blotting和细胞迁移和侵袭实验，探讨let-7 f-1 - 3 p在非小细胞肺癌（NSCLC）中的作用及对阿霉素（DOX）治疗的影响。癌组织中let-7 f-1- 3 p表达水平低于癌旁组织。因此，let-7 f-1- 3 p可能是一个抑制基因。本研究还探讨了let-7 f-1- 3 p在A549和NCI-H1975细胞中的作用。结果显示let-7 f-1- 3 p能抑制NSCLC细胞的生长、迁移和侵袭能力，并诱导其凋亡。整合素β1是let-7 f-1- 3 p调控的靶基因。这表明let-7 f-1- 3 p可以增强体外DOX抑制的细胞活力、迁移和侵袭。总之，本研究表明let-7 f-1- 3 p可能作为药物设计和肺癌治疗的靶点。
Lung cancer is one of the most common types of cancer, with the highest mortality rate worldwide. MicroRNAs play notable roles in the chemotherapeutic effects of anticancer drugs. The present study used reverse transcription-quantitative PCR, western blotting and cell migration and invasion assays to reveal the role of let-7f-1-3p in non-small cell lung cancer (NSCLC) and explore the effect of let-7f-1-3p on doxorubicin (DOX) treatment. It was demonstrated that the levels of let-7f-1-3p in carcinoma tissues were lower compared with those in paracarcinoma tissues. Thus, let-7f-1-3p may act as a suppressor gene. The present study also explored the role of let-7f-1-3p in A549 and NCI-H1975 cells. Results revealed that let-7f-1-3p could inhibit the viability, migration and invasion of NSCLC cells and induce their apoptosis. Integrin β1 acted as a target gene regulated by let-7f-1-3p. This suggested that let-7f-1-3p could enhance DOX-inhibited cell viability, migration and invasion in vitro. Overall, the present study demonstrated that let-7f-1-3p may act as a target for drug design and lung cancer therapy.
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