Continuous Expression of I‐A Antigen by Peritoneal Macrophages From Mice Resistant to Mycobacterium bovis (Strain BCG)
Continuous Expression of I‐A Antigen by Peritoneal Macrophages From Mice Resistant to Mycobacterium bovis (Strain BCG)
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抗牛分枝杆菌（BCG 株）小鼠腹膜巨噬细胞持续表达 I-A 抗原
DOI：
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发表时间：
1985
影响因子：
5.5
通讯作者：
B. Zwilling
中科院分区：
文献类型：
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作者：
Sarah C. Johnson;B. Zwilling
使用单克隆抗体监测从牛分枝杆菌（BCG菌株）免疫小鼠获得的巨噬细胞表面上I-A抗原的表达。与李斯特菌注射小鼠巨噬细胞表达I-A的瞬时性质不同，28天前注射104 BCG的小鼠腹腔巨噬细胞持续表达I-A。持续表达不是由于抗原或污染淋巴细胞的存在。当我们比较不同品系小鼠的I-A表达动力学时，I-A的持续表达与小鼠对BCG的遗传抗性相关。来自BCG抗性小鼠的巨噬细胞持续表达I-A，而来自BCG易感小鼠的巨噬细胞瞬时表达I-A。用鼠伤寒沙门氏菌注射耐药小鼠不会诱导持续表达I-A的巨噬细胞群体。这表明Bcg基因可能与负责对沙门氏菌（Ity）或利什曼原虫（Lsh）的抗性的基因不同。
Monoclonal antibodies were used to monitor the expression of I‐A antigen on the surface of macrophages obtained from mice immunized to Mycobacterium bovis (strain BCG). Unlike the transient nature of I‐A expression by macrophages from Listeria‐injected mice, peritoneal macrophages from mice injected 28 days previously with 104 BCG expressed I‐A continuously. The continued expression was not due to the presence of antigen or of contaminating lymphocytes. When we compared the kinetics of I‐A expression from different strains of mice, the continuous expression of I‐A correlated with the genetic resistance of the mice to BCG. Macrophages from mice that were resistant to BCG expressed I‐A continuously, while macrophages from BCG susceptible mice expressed I‐A transiently. Injection of resistant mice with Salmonella typhimurium did not result in the induction of a population of macrophages that expressed I‐A continuously. This suggests that the Bcg gene may not be the same as that responsible for resistance to Salmonella (Ity) or Leishmania (Lsh).
证明感染低剂量 BCG 蒙特利尔的 Bcgr 近交小鼠品系具有获得性抗性。
影响因子：
4.6
作者：
Orme,IM;Collins,FM
通讯作者：
Collins,FM
DOI：
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发表时间：
1981
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Beller,DI;Unanue,ER
通讯作者：
Unanue,ER