Poor trail making test performance is directly associated with altered dual task prioritization in the elderly--baseline results from the TREND study.
Poor trail making test performance is directly associated with altered dual task prioritization in the elderly--baseline results from the TREND study.
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DOI：
10.1371/journal.pone.0027831
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Maetzler W
中科院分区：
文献类型：
--
作者：
Hobert MA;Niebler R;Meyer SI;Brockmann K;Becker C;Huber H;Gaenslen A;Godau J;Eschweiler GW;Berg D;Maetzler W
老年人执行功能的恶化与行走能力的损害有关。这可能是由有限的认知灵活性和工作记忆造成的，但也可能是同时执行的任务的优先顺序改变造成的。为了理清这些选项，我们调查了连线测试成绩(专门衡量认知灵活性和工作记忆)和双重任务成本(衡量优先顺序)之间的关联。在趋势研究(Tuebinger评估早期发现神经退行性疾病的危险因素)中，686名50至80岁的神经退行性健康、非痴呆老年人根据他们的连线测试表现(Delta TMT；TMT-B减去TMT-A)进行分类。受试者以习惯性和最大速度进行20m步行。双重任务表现的测试是以最快速度行走，结合剪贴板上的复选框，并以最快速度减去序号7 S。正如预期的那样，在单任务和双任务条件下，较差的管理层在减去序列7 S时的表现更差，而在同时减去序列7 S时，他们的行走速度比成绩好的组慢。在减去连续7个S状态而不是在其他3个状态下的行走中，TMT表现差者的双重任务成本(中位数20%；−6~58%)高于表现良好者(17%；−16%~43%；p<；0.001)。相反，在双任务情境下，任务管理绩效差组出现计算错误的比例低于单任务情境，但在任务绩效好组中却高于单任务任务组(差任务组，−1.6%；好任务组，+3%；p = 0.035)。在最具挑战性的条件下，TMT表现不佳的老年人优先考虑认知任务，而不是步行速度。这表明，较差的认知灵活性和工作记忆与优先顺序的改变直接相关。
Deterioration of executive functions in the elderly has been associated with impairments in walking performance. This may be caused by limited cognitive flexibility and working memory, but could also be caused by altered prioritization of simultaneously performed tasks. To disentangle these options we investigated the associations between Trail Making Test performance—which specifically measures cognitive flexibility and working memory—and dual task costs, a measure of prioritization. Out of the TREND study (Tuebinger evaluation of Risk factors for Early detection of Neurodegenerative Disorders), 686 neurodegeneratively healthy, non-demented elderly aged 50 to 80 years were classified according to their Trail Making Test performance (delta TMT; TMT-B minus TMT-A). The subjects performed 20 m walks with habitual and maximum speed. Dual tasking performance was tested with walking at maximum speed, in combination with checking boxes on a clipboard, and subtracting serial 7 s at maximum speeds. As expected, the poor TMT group performed worse when subtracting serial 7 s under single and dual task conditions, and they walked more slowly when simultaneously subtracting serial 7 s, compared to the good TMT performers. In the walking when subtracting serial 7 s condition but not in the other 3 conditions, dual task costs were higher in the poor TMT performers (median 20%; range −6 to 58%) compared to the good performers (17%; −16 to 43%; p<0.001). To the contrary, the proportion of the poor TMT performance group that made calculation errors under the dual tasking situation was lower than under the single task situation, but higher in the good TMT performance group (poor performers, −1.6%; good performers, +3%; p = 0.035). Under most challenging conditions, the elderly with poor TMT performance prioritize the cognitive task at the expense of walking velocity. This indicates that poor cognitive flexibility and working memory are directly associated with altered prioritization.
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影响因子：
2
作者：
Bloem, BR;Valkenburg, VV;van Dijk, JG
通讯作者：
van Dijk, JG
影响因子：
2.4
作者：
Bloem, BR;Valkenburg, VV;Willemsen, MD
通讯作者：
Willemsen, MD
DOI：
10.1186/1744-9081-6-59
发表时间：
2010-10-12
期刊：
Behavioral and brain functions : BBF
影响因子：
--
作者：
de Bruin ED;Schmidt A
通讯作者：
Schmidt A
DOI：
10.1093/gerona/54.8.m428
发表时间：
1999-08-01
影响因子：
5.1
作者：
Binder, EF;Storandt, M;Birge, SJ
通讯作者：
Birge, SJ
影响因子：
6.7
作者：
Beauchet, Olivier;Dubost, Veronique;Kressig, Reto W.
通讯作者：
Kressig, Reto W.