Two dogs with iatrogenic discospondylitis caused by meticillin-resistant Staphylococcus aureus
Two dogs with iatrogenic discospondylitis caused by meticillin-resistant Staphylococcus aureus
复制标题
DOI：
10.1111/j.1748-5827.2008.00720.x
复制
发表时间：
2009-04-01
影响因子：
1.6
通讯作者：
Tipold, A.
中科院分区：
文献类型：
--
作者：
Schwartz, M.;Boettcher, I. C.;Tipold, A.
两只狗在胸腰椎半椎板切除术后发生了由耐甲氧西林金黄色葡萄球菌引起的椎间盘脊柱炎。诊断分别通过磁共振成像和放射照相术结合微生物拭子培养建立。首先开始β-内酰胺类抗生素治疗。一旦获得培养结果，确认耐甲氧西林金黄色葡萄球菌感染，并获得细菌培养图，则将抗菌治疗改为庆大霉素和甲氧苄啶/磺胺嘧啶。然而，一只狗进一步恶化并被安乐死。另一只狗在适当的治疗后有所改善。手术后四个月第一次尝试停止药物治疗导致复发。然后开始使用氯霉素进行抗菌治疗，并再维持4个月。这只狗在2.5年内没有任何复发。兽医在选择抗生素进行初始抗菌治疗时，应意识到耐甲氧西林金黄色葡萄球菌可能参与术后椎间盘脊柱炎，同时培养结果仍悬而未决。
Two dogs developed discospondylitis caused by meticillin-resistant Staphylococcus aureus following thoracolumbar hemilaminectomy. Diagnoses were established by magnetic resonance imaging and radiography, respectively, in conjunction with culturing of microbial swabs. Treatment with beta-lactam antibiotics was first initiated. As soon as culturing results, confirming meticillin-resistant Staphylococcus aureus infection, and antibiograms became available, antimicrobial therapy was changed to gentamicin and trimethoprim/sulphadiazine. One dog, however, deteriorated further and was euthanased. The other dog improved on appropriate therapy. The first attempt to discontinue drug therapy four months after surgery led to a relapse. Antimicrobial therapy with chloramphenicol was then initiated and maintained for an additional four months. This dog is free of any relapses for 2.5 years. The veterinary surgeon should be aware of the possible involvement of meticillin-resistant Staphylococcus aureus in postsurgical discospondylitis when choosing an antibiotic for initial antimicrobial therapy while culturing results are still pending.