Reduced inspired oxygen decreases retinal superoxide radicals and promotes cone function and survival in a model of retinitis pigmentosa.
Reduced inspired oxygen decreases retinal superoxide radicals and promotes cone function and survival in a model of retinitis pigmentosa.
复制标题
减少吸入氧可减少视网膜超氧自由基，并促进色素性视网膜炎模型中视锥细胞的功能和存活。
DOI：
10.1016/j.freeradbiomed.2023.01.021
复制
发表时间：
2023
影响因子：
7.4
通讯作者：
Campochiaro,PeterA
中科院分区：
文献类型：
--
作者：
Kanan,Yogita;Hackett,SeanF;Hsueh,HenryT;Khan,Mahmood;Ensign,LauraM;Campochiaro,PeterA
色素性视网膜炎 (RP) 是由许多不同的突变引起的，这些突变会促进视杆细胞感光细胞的变性，但对视锥细胞没有直接影响。大多数视杆细胞死亡后，视锥细胞感光器开始缓慢退化。氧化损伤会导致视锥细胞死亡，并且据推测，由于视杆细胞损失导致耗氧量减少而导致组织高氧，从而引发了氧化应激。在此，我们在 RP 动物模型中证明，通过将吸入氧减少到持续呼吸 11% O2 来减少视网膜高氧，从而减少视网膜中超氧自由基的产生，并保留视锥细胞结构和功能。这些数据表明，视网膜高氧是促进 RP 视网膜氧化损伤、视锥细胞功能丧失和视锥细胞变性的起始事件。
Retinitis pigmentosa (RP) is caused by many different mutations that promote the degeneration of rod photoreceptors and have no direct effect on cones. After the majority of rods have died cone photoreceptors begin to slowly degenerate. Oxidative damage contributes to cone cell death and it has been hypothesized that tissue hyperoxia due to reduced oxygen consumption from the loss of rods is what initiates oxidative stress. Herein, we demonstrate in animal models of RP that reduction of retinal hyperoxia by reducing inspired oxygen to continuous breathing of 11% O2reduced the generation of superoxide radicals in the retina and preserved cone structure and function. These data indicate that retinal hyperoxia is the initiating event that promotes oxidative damage, loss of cone function, and cone degeneration in the RP retina.