Diabetes, cardiovascular disease, selected cardiovascular disease risk factors, and the 5-year incidence of age-related cataract and progression of lens opacities. The Beaver Dam Eye Study
Diabetes, cardiovascular disease, selected cardiovascular disease risk factors, and the 5-year incidence of age-related cataract and progression of lens opacities. The Beaver Dam Eye Study
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DOI：
10.1016/s0002-9394(98)00280-3
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发表时间：
1998-12-01
影响因子：
4.2
通讯作者：
Lee, KE
中科院分区：
文献类型：
--
作者：
Klein, BEK;Klein, R;Lee, KE
目的：描述以下关系：糖尿病、心血管疾病；并选择心血管疾病危险因素，以 5 年为间隔，影响年龄相关性白内障的累积发生率和晶状体混浊的进展。 方法：在基线评估 5 年后，对 Beaver Dam 眼科研究队列进行后续检查。基线之前的人口普查年龄范围为 43 岁至 84 岁。两项检查的检查方案、晶状体摄影和分级均相同。 结果：对于所有白内障，在无糖尿病的患者中，基线年龄是与核白内障、皮质白内障和后囊下白内障发病率相关的最显着特征（P < .001）。年龄与白内障之间存在正相关关系，在较差的眼睛中发现核白内障和皮质白内障（P 小于或等于 0.04），但在糖尿病患者中与后囊下白内障无关。核硬化的进展很常见，在考虑任何一只眼睛时，约 70% 的受试者会发生核硬化。糖尿病患者中，发生皮质和后囊下白内障（对于每个病变较差的眼睛，P 小于或等于 0.001）以及皮质和后囊下混浊的进展在糖尿病患者中更为常见（对于每个病变，任一只眼睛的 P 小于或等于 0.001）。糖化血红蛋白水平升高与糖尿病患者患核性白内障和皮质性白内障的风险增加相关。危险因素与后囊下白内障的关系，尤其是糖尿病患者，往往符合预期的方向，但可能由于样本量小而缺乏显着性。 结论：糖尿病与 5 年以上皮质和后囊下白内障的发病率以及更轻微的皮质和后囊下晶状体混浊的进展有关。这些变化可能与血糖水平有关。心血管疾病及其危险因素影响不大。任何与年龄相关的白内障的发病率。 （Am J Ophamol 1998；126：782-790，(C) 1998，Elsevier Science Inc. 保留所有权利，）。
PURPOSE: To describe the relationships of: diabetes mellitus, cardiovascular disease; and selected cardiovascular disease risk factors to cumulative incidence of age-related cataract and to progression of lens opacities over a 5-year interval.METHODS: A follow-up examination of the Beaver Dam Eye Study cohort was performed 5 years after the baseline evaluation. Ages at the census prior to baseline ranged from 43 to 84 years of age. Protocols for examination, lens photography, and grading were the same for both examinations.RESULTS: Age at baseline was the most significant characteristic associated with incidence of nuclear, cortical, and posterior subcapsular cataract in those without diabetes (P < .001) for all cataracts. The positive association of age with cataract was found for nuclear and cortical cataract in the worse eye (P less than or equal to .04) but not posterior subcapsular cataract in those with diabetes, Progression of nuclear sclerosis was common, occurring in about 70% of subjects when considering either eye. Incident cortical and posterior subcapsular cataracts (P less than or equal to .001 for worse eye for each lesion) and progression of cortical and posterior subcapsular opacities were more common in those with diabetes (P less than or equal to .001 for either eye for each lesion). Increased glycated hemoglobin level was associated with increased risk of nuclear and cortical cataracts in these with diabetes. Relationships of risk factors to posterior subcapsular cataracts, especially among those with diabetes, were often in the expected direction but lacked significance possibly due to small samples.CONCLUSIONS: Diabetes mellitus is associated with incidence over 5 years of cortical and posterior subcapsular cataract and with progression of more minor cortical and posterior subcapsular lens opacities. These changes may be related to level of glycemia. Cardiovascular disease and its risk factors have little effect. on incidence of any age-related cataract. (Am J Ophthalmol 1998;126: 782-790, (C) 1998 by Elsevier Science Inc. All rights reserved,).