Evidence for the combined participation of a C10 and a C15 precursor in the biosynthesis of moenocinol, the lipid part of the moenomycin antibiotics
Evidence for the combined participation of a C10 and a C15 precursor in the biosynthesis of moenocinol, the lipid part of the moenomycin antibiotics
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DOI：
10.1002/cbic.200300622
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发表时间：
2003-11-07
期刊：
影响因子：
3.2
通讯作者：
Welzel, P
中科院分区：
文献类型：
--
作者：
Neundorf, I;Köhler, C;Welzel, P
在将[2-C-13，4 - 2 H]-1-脱氧-D-木酮糖喂入加纳链霉菌后，氘标记仅保留在默诺霉素抗生素的默诺酚部分的C-7和C-17位。这一结果证实了如下假设：moenocinol的C-25结构是由C-10和C-15前体组装而成的，每种前体的形成都需要二甲基烯丙基二磷酸起始单元的参与。
Upon feeding of [2-C-13,4-2H]-1-deoxy-D-xylulose to Streptomyces ghanaensis, the deuterium label was retained exclusively at positions C-7 and C-17 in the moenocinol part of the moenomycin antibiotics. This result vindicates the hypothesis that the C-25 structure of moenocinol is assembled from a C-10 and a C-15 precursor each of which requires for its formation the involvement of a dimethylallyl diphosphate starter unit.