Survival among US women with invasive epithelial ovarian cancer
Survival among US women with invasive epithelial ovarian cancer
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DOI：
10.1006/gyno.2001.6536
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发表时间：
2002-03-01
影响因子：
4.7
通讯作者：
Whittemore, AS
中科院分区：
文献类型：
--
作者：
McGuire, V;Jesser, CA;Whittemore, AS
客观的。侵袭性上皮性卵巢癌是一种高度致命的疾病，在晚期诊断时生存率很低。人们对不同种族/族裔的美国女性的生存差异知之甚少。为了研究这个问题，我们评估了来自六个种族/族裔群体的基于人群的患者样本中浸润性上皮性卵巢癌的病理特征和死亡率。方法。该分析包括 1973 年至 1997 年间在国家癌症研究所的监测、流行病学和最终结果项目中被诊断患有原发性浸润性上皮性卵巢癌的 38,012 名女性。结果。与白人相比，菲律宾患者诊断时更年轻，更有可能患有局部疾病，并且患有更多的粘液癌。非洲裔美国人比白人更有可能在年龄较大时被诊断出患有远处疾病和未分化/未分类的癌症。在调整诊断时的年龄、诊断时的疾病阶段和癌症组织学之后，我们发现，与白人相比，非裔美国人的死亡率显着升高，而西班牙裔和菲律宾人的死亡率显着降低。我们还发现，晚期疾病女性的死亡率随着时间的推移而显着下降。结论。患有晚期疾病的女性死亡率下降表明这些女性之间存在相当大的预后异质性，这可能反映了护理质量的差异。这个问题以及非裔美国妇女的生存劣势以及西班牙裔和菲律宾妇女的生存优势都需要调查。 (C) 2002 年爱思唯尔科学（美国）。
Objective. Invasive epithelial ovarian cancer is a highly fatal disease, diagnosed at advanced stages when survival is poor. Relatively little is known about the variation in survival across U.S. women of different race/ethnicities. To investigate this issue, we evaluated pathological characteristics and death rates due to invasive epithelial ovarian cancer in a population-based sample of patients from six racial/ethnic groups.Methods. The analysis included 38,012 women diagnosed with primary invasive epithelial ovarian cancer between 1973 and 1997 in the Surveillance, Epidemiology and End Results Program of the National Cancer Institute.Results. Filipina patients were younger at diagnosis, more likely to have localized disease, and had more mucinous cancers than whites. African-Americans were more likely than whites to be diagnosed at older ages, with distant disease and with undifferentiated/unclassified cancers. After adjusting for age at diagnosis, stage of disease at diagnosis, and cancer histology, we found that, compared to whites, death rates were significantly elevated among African-Americans and significantly reduced among Hispanics and Filipina. We also found that death rates declined significantly with time since diagnosis among women with advanced disease.Conclusion. The declining death rates in women with advanced disease suggest the presence of considerable prognostic heterogeneity among these women, which could reflect differences in quality of care. This issue, as well as the survival disadvantage for African-American women and survival advantages for Hispanic and Filipina women, needs investigation. (C) 2002 Elsevier Science (USA).