Anthracycline-induced acute cardiotoxicity in adults treated for leukaemia - Analysis of the clinico-pathological aspects of documented acute anthracycline-induced cardiotoxicity inpatients treated for acute leukaemia at the University Hospital of Zurich, Switzerland, between 1990 and 1996
Anthracycline-induced acute cardiotoxicity in adults treated for leukaemia - Analysis of the clinico-pathological aspects of documented acute anthracycline-induced cardiotoxicity inpatients treated for acute leukaemia at the University Hospital of Zurich, Switzerland, between 1990 and 1996
复制标题
DOI：
10.1023/a:1011196910325
复制
发表时间：
2001-07-01
影响因子：
50.5
通讯作者：
Follath, F
中科院分区：
文献类型：
--
作者：
Dazzi, H;Kaufmann, K;Follath, F
背景：蒽环类药物引起的急性心脏毒性是一种罕见的，但危及生命的事件。个体间对蒽环类药物的敏感性是高度可变的，不能预测为个别patient.Patients和方法：这是一项回顾性研究。回顾了1990年至1996年在瑞士苏黎世大学医院接受急性白血病治疗的患者的病历和尸检报告，并检索了蒽环类药物相关的急性心脏毒性。已知与心脏毒性相关的预先存在的心脏病患者被排除在外。结果：7例白血病治疗证明蒽环类药物相关的急性心脏毒性被列入。在6名患者中，死亡的直接原因是治疗引起的急性心脏毒性。一名患者从心力衰竭中恢复，但几个月后死于难治性白血病。临床症状为心力衰竭。病理结果为扩张性心肌肥厚和心包积液。在显微镜下，心肌纤维化和核周空泡化的心肌细胞的典型结果seeed.Conclusions：急性心功能的蒽环类药物的不良反应的认识，促进心力衰竭的早期识别和预防。需要可靠的测试来早期诊断亚临床心肌损伤，以识别有风险的患者。
Background: Acute cardiotoxicity due to anthracyclines is a rare, but life-threatening event. Interindividual sensitivity to anthracyclines is highly variable and cannot be predicted for the individual patient.Patients and methods: This is a retrospective study. Medical charts and autopsy reports of patients treated for acute leukemia between 1990 and 1996 at the University Hospital of Zurich, Switzerland were reviewed and searched for anthracycline-associated acute cardiotoxicity. Patients with pre-existing heart disease known to be associated with cardiotoxicity were excluded.Results: Seven patients treated for leukemia with proven anthracycline-associated acute cardiotoxicity were included. In six patients the direct cause of death was acute cardiotoxicity due to the treatment. One patient recovered from cardiac failure but died a few months later from refractory leukemia. Clinical symptoms were those of a heart failure. Pathological findings were dilatative cardiac hypertrophy and pericardial effusion. Microscopically the typical findings of myocardial fibrosis and perinuclear vacuolisated myocytes were seen.Conclusions: The awareness of acute adverse effects on cardiac performance by anthracyclines faciliates early recognition and prevention of heart failure. Reliable tests are needed for the early diagnosis of subclinical myocardial damage in order to identify patients at risk.