A sunblock based on bioadhesive nanoparticles.
A sunblock based on bioadhesive nanoparticles.
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DOI：
10.1038/nmat4422
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发表时间：
2015-12
期刊：
影响因子：
41.2
通讯作者：
Saltzman WM
中科院分区：
文献类型：
--
作者：
Deng Y;Ediriwickrema A;Yang F;Lewis J;Girardi M;Saltzman WM
大多数商业防晒制剂使用有机或无机紫外线（UV）过滤剂。尽管可以防止皮肤光毒性，但直接暴露于紫外线过滤剂的细胞引起了各种健康问题。在这里，我们表明，包封padimate O（PO）-一个模型的紫外线过滤器-在生物粘附性纳米粒子（BNP）防止表皮细胞暴露于紫外线过滤器，同时增强紫外线保护。BNP容易悬浮在水中，促进粘附到角质层而没有随后的表皮内或毛囊渗透，并且它们与皮肤的相互作用是防水的，但是颗粒可以通过主动毛巾干燥去除。尽管基于BNP的防晒霜含有小于5重量%的市售标准品中发现的UV过滤剂浓度，但当在两种鼠模型中测试时，抗UV效果是相当的。此外，与商业防晒制剂相比，基于BNP的防晒霜显着减少了双链DNA断裂。
The majority of commercial sunblock preparations utilize organic or inorganic ultraviolet (UV) filters. Despite protecting against cutaneous phototoxicity, direct cellular exposure to UV filters has raised a variety of health concerns. Here, we show that the encapsulation of padimate O (PO) - a model UV filter - in bioadhesive nanoparticles (BNPs) prevents epidermal cellular exposure to UV filters while enhancing UV protection. BNPs are readily suspended in water, facilitate adherence to the stratum corneum without subsequent intra-epidermal or follicular penetration, and their interaction with skin is water-resistant yet the particles can be removed via active towel drying. Although the sunblock based on BNPs contained less than 5 wt% of the UV-filter concentration found in commercial standards, the anti-UV effect was comparable when tested in two murine models. Moreover, the BNP-based sunblock significantly reduced double-stranded DNA breaks when compared to a commercial sunscreen formulation.