Testosterone replacement increases fat-free mass and muscle size in hypogonadal men
Testosterone replacement increases fat-free mass and muscle size in hypogonadal men
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DOI：
10.1210/jc.82.2.407
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发表时间：
1997-02-01
影响因子：
5.8
通讯作者：
Casaburi, R
中科院分区：
文献类型：
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作者：
Bhasin, S;Storer, TW;Casaburi, R
睾丸激素导致去势雄性动物的氮滞留，以及雄性和雌性动物肌肉大小与性别有关的差异，被认为是睾丸激素具有合成代谢作用的证据。然而，睾酮对身体成分和肌肉大小的影响还没有得到严格的研究。本研究的目的是在控制营养摄入量和运动水平的情况下，确定替代剂量的睾酮对健康性腺功能低下男性脱脂质量和肌肉大小的影响。7名性腺功能低下的男性，19-47岁，经过至少12周的雄激素治疗后，接受了10周的注射，每次100毫克/周。治疗前后分别评估体重、水下称重法和重水稀释法测量的脱脂质量、磁共振成像测量的肌肉大小。能量和蛋白质摄入量标准为35卡路里/公斤。D，1.5g/kg。分别是一天。睾酮替代治疗10周后，体重由治疗前的79.2±-5.6 kg增加到83.7±-5.7 kg(体重增加4.5±-0.6 kg；P=0.0064)。水下称重法测得的脱脂质量从56.0±-2.5 kg增加到6 0.9±-2.2 kg(变化为+5.0+-0.7 kg；P=0.0004)，但脂肪百分比无明显变化。去脂体重的增加与去氢水法相似。经核磁共振测量，臂三头肌横截面积由2 421±/-317增加至2 721±/-239 mm(2)(P=0.045)，小腿四头肌横截面积由7 173±/-464增加至7720+/-454 mm(2)(P=0.0427)。通过一次重复的最大举重练习来评估肌肉力量，在睾丸激素治疗后显著增加。治疗10周后，L-[1-C-13]亮氨酸转换率、亮氨酸氧化和亮氨酸非氧化消失率均无明显变化。患者的血红蛋白、红细胞压积、肌酐和转氨酶水平没有显著变化。替代剂量的睾酮增加了性腺功能减退男性的脱脂质量、肌肉大小和力量。在以低睾酮水平为特征的消瘦状态下，雄激素替代是否会有类似的合成代谢作用仍有待研究。
Testosterone-induced nitrogen retention in castrated male animals and sex-related differences in the size of the muscles in male and female animals have been cited as evidence that testosterone has anabolic effects. However, the effects of testosterone on body composition and muscle size have not been rigorously studied. The objective of this study was to determine the effects of replacement doses of testosterone on fat-free mass and muscle size in healthy hypogonadal men in the setting of controlled nutritional intake and exercise level. Seven hypogonadal men, 19-47 yr of age, after at least a 12-week washout from previous androgen therapy, were treated for 10 weeks with testosterone enanthate (100 mg/week) by im injections. Body weight, fat-free mass measured by underwater weighing and deuterated water dilution, and muscle size measured by magnetic resonance imaging were assessed before and after treatment. Energy and protein intake were standardized at 35 Cal/kg . day and 1.5 g/kg . day, respectively. Body weight increased significantly from 79.2 +/- 5.6 to 83.7 +/- 5.7 kg after 10 weeks of testosterone replacement therapy (weight gain, 4.5 +/- 0.6 kg; P = 0.0064). Fat-free mass, measured by underwater weighing, increased from 56.0 +/- 2.5 to 60.9 +/- 2.2 kg(change, +5.0 +/- 0.7 kg; P = 0.0004), but percent fat did not significantly change. Similar increases in fat-free mass were observed with the deuterated water method. The cross-sectional area of the triceps arm muscle increased from 2421 +/- 317 to 2721 +/- 239 mm(2) (P = 0.045), and that of the quadriceps leg muscle increased from 7173 +/- 464 to 7720 +/- 454 mm(2) (P = 0.0427), measured by magnetic resonance imaging. Muscle strength, assessed by one repetition maximum of weight-lifting exercises increased significantly after testosterone treatment. L-[1-C-13]Leucine turnover, leucine oxidation, and nonoxidative disappearance of leucine did not significantly change after 10 weeks of treatment. There was no significant change in hemoglobin, hematocrit, creatinine, and transaminase levels.Replacement doses of testosterone increase fat-free mass and muscle size and strength in hypogonadal men. Whether androgen replacement in wasting states characterized by low testosterone levels will have similar anabolic effects remains to be studied.