Use of an electronic monitoring system for self-reporting smallpox vaccine reactions
Use of an electronic monitoring system for self-reporting smallpox vaccine reactions
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DOI：
10.1089/bsp.2005.3.198
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发表时间：
2005-01-01
期刊：
影响因子：
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通讯作者：
Lurie, N
中科院分区：
文献类型：
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作者：
Olmsted, SS;Grabenstein, JD;Lurie, N
目的：在大规模疫苗接种计划（如最近的天花计划或大流行性流感爆发）期间跟踪疫苗反应和不良事件将是一项挑战。我们报告使用一种新的基于电话和网络的电子报告系统收集的疫苗反应数据。该系统被用于在美国陆军的天花疫苗接种活动中监测接种者，这是预防生物攻击的国家计划的一部分。此外，我们还根据自我报告的数据报告了接种天花疫苗后事件的时间进程，并评估了自我报告接种天花疫苗后服用信息的有效性和可靠性。方法：一个前瞻性队列的受试者自愿接受天花疫苗接种，使用电子监测系统跟踪和报告他们的接种反应。用户使用电子监测系统进行6.8 +/- 6.2（平均SD）报告。自我报告的敏感性和阳性预测值分别为98.8%和99.6%。接种现场的反应进展速度更快的revaccinees比第一次vaccinees.Conclusions：简单易用的电话/互联网为基础的技术允许详细的自我记录的响应门诊天花疫苗接种。自我报告现场外观足以确定疫苗接种在大多数疫苗接种者。在大规模疫苗接种事件期间，电子监测系统可以促进疫苗反应的跟踪，包括为不良事件提供早期预警系统，并可能减少与医疗保健专业人员随访相关的负担。
Objectives: Tracking vaccine reactions and adverse events during a large-scale vaccination program such as the recent smallpox program or a pandemic flu outbreak will be a challenge. We report on vaccine reaction data collected using a novel telephone- and web-based electronic reporting system. The system was used to monitor vaccinees during the U.S. Army's smallpox vaccination campaign, which was part of the national program to prepare against biological attack. In addition, we report on the time course of events after smallpox vaccination based on the self-reported data and evaluate the validity and reliability of self-reported take information after smallpox vaccination.Methods: A prospective cohort of subjects receiving the smallpox vaccination volunteered to use an electronic monitoring system to track and report their vaccination reactions.Results: Users made 6.8 +/- 6.2 (mean SD) reports using the electronic monitoring system. The sensitivity and positive predictive value of self-reported takes were high, 98.8% and 99.6%, respectively. The vaccination-site reactions progressed faster for revaccinees than first-time vaccinees.Conclusions: Simple-to-use telephone/Internet-based technology allowed detailed self-recording of response to smallpox vaccination among outpatients. Self-reports on site appearance were sufficient to determine vaccine takes in most vaccinees. During a mass vaccination event, an electronic monitoring system could facilitate tracking of vaccine reactions, including providing an early warning system for adverse events, and might reduce the burden associated with follow-up visits with healthcare professionals.