Pathway Profiling in Mycobacterium tuberculosis : Elucidation of a Cholesterol-Derived Catabolite and the Enzymes that Catalyze its Metabolism
Pathway Profiling in Mycobacterium tuberculosis : Elucidation of a Cholesterol-Derived Catabolite and the Enzymes that Catalyze its Metabolism
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发表时间：
2011
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通讯作者：
Suzanne T Thomas;B. VanderVen;D. Sherman;D. Russell;N. Sampson
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作者：
Suzanne T Thomas;B. VanderVen;D. Sherman;D. Russell;N. Sampson
背景：胆固醇代谢在结核分枝杆菌感染的慢性期至关重要。结果：确定了胆固醇代谢产物的结构和负责其降解的酶活性。结论：igr操纵子编码催化胆固醇侧链降解最后三步的酶。重要性：深入了解igr操纵子中编码的酶的功能对于理解胆固醇代谢在发病机制中的作用是重要的。
Background: Cholesterol metabolism is critical in the chronic phase of Mycobacterium tuberculosis infection. Results: A cholesterol metabolite structure and an enzyme activity responsible for its degradation were determined. Conclusion: The igr operon encodes the enzymes that catalyze the final three steps in cholesterol side-chain degradation. Significance: Insight into the function of enzymes encoded in the igr operon is important for understanding the role of cholesterol metabolism in pathogenesis.