Colorectal cancer expression of peroxisome proliferator-activated receptor gamma (PPARG, PPARgamma) is associated with good prognosis.
Colorectal cancer expression of peroxisome proliferator-activated receptor gamma (PPARG, PPARgamma) is associated with good prognosis.
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DOI：
10.1053/j.gastro.2008.12.048
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发表时间：
2009-04
期刊：
影响因子：
29.4
通讯作者：
Fuchs CS
中科院分区：
文献类型：
--
作者：
Ogino S;Shima K;Baba Y;Nosho K;Irahara N;Kure S;Chen L;Toyoda S;Kirkner GJ;Wang YL;Giovannucci EL;Fuchs CS
The peroxisome proliferator-activated receptor-γ (PPARG) is a nuclear receptor that regulates expression of mediators of lipid metabolism and the inflammatory response. There is controversy over the pro- or anti-oncogenic effects of PPARG and little is known about how its expression correlates with prognosis in patients with colon cancer. Among 470 colorectal cancer patients (stages I-IV) identified in 2 independent prospective cohorts, PPARG expression was detected in 102 tumors (22%) by immunohistochemistry. Cox proportional hazard models computed hazard ratios (HRs) of colorectal cancer-specific and overall mortalities, unadjusted and adjusted for patient characteristics and tumor molecular features, including cyclooxygenase-2 (COX-2), fatty acid synthase (FASN), KRAS, BRAF, PIK3CA, p53, p21, β-catenin, LINE-1 hypomethylation, microsatellite instability (MSI) and the CpG island methylation phenotype (CIMP). Compared to patients with PPARG-negative tumors, patients with PPARG-positive tumors had significantly lower overall mortality, determined by Kaplan-Meier analysis (p=0.0047), univariate Cox regression (HR 0.55; 95% confidence interval [CI], 0.37-0.84; p=0.0053) and multivariate analysis (adjusted HR 0.43; 95% CI, 0.27-0.69; p=0.0004). Patients with PPARG-positive tumors experienced a lower colorectal cancer-specific mortality (HR 0.65; 95% CI, 0.40-1.07; p=0.092), which became significant in multivariate analysis (adjusted HR 0.44; 95% CI, 0.25-0.79; p=0.0054). The relationship between PPARG and lower mortality did not appear to be significantly modified by tumor stage or the other clinical and molecular variables examined (all Pinteraction>0.05). Tumor expression of PPARG is independently associated with longer survival of patients. PPARG expression appears to mark an indolent subset of colorectal cancers.
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影响因子：
24.5
作者：
Ogino, S.;Cantor, M.;Fuchs, C. S.
通讯作者：
Fuchs, C. S.
影响因子：
6.4
作者：
Gustafsson, Annika;Hansson, Elisabeth;Lundholm, Kent
通讯作者：
Lundholm, Kent
影响因子：
82.9
作者：
Lefebvre, AM;Chen, IH;Auwerx, J
通讯作者：
Auwerx, J
影响因子：
24.5
作者：
Ogino S;Nosho K;Kirkner GJ;Kawasaki T;Meyerhardt JA;Loda M;Giovannucci EL;Fuchs CS
通讯作者：
Fuchs CS
影响因子：
29.4
作者：
Konishi, Kazuo;Shen, Lanlan;Issa, Jean-Pierre J.
通讯作者：
Issa, Jean-Pierre J.