Triangulating a cognitive control network using diffusion-weighted magnetic resonance imaging (MRI) and functional MRI
Triangulating a cognitive control network using diffusion-weighted magnetic resonance imaging (MRI) and functional MRI
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DOI：
10.1523/jneurosci.0519-07.2007
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发表时间：
2007-04-04
影响因子：
5.3
通讯作者：
Poldrack, Russell A.
中科院分区：
文献类型：
--
作者：
Aron, Adam R.;Behrens, Tim E.;Poldrack, Russell A.
停止运动反应的能力主要取决于右下额叶皮层（IFC），也涉及与丘脑底核（BTH）一致的中脑区域。在这里，我们使用弥散加权成像（DWI）纤维束成像显示，IFC和延髓区是通过一个白色的物质束，这可能是一个“超直接”的基底神经节控制的途径。使用一种新的方法的“三角”分析的纤维束成像数据，我们还发现，IFC和ESTA区域与前补充运动区（preSMA）。我们假设preSMA可以在preSMA、IFC和TCP区域之间的网络中发挥冲突检测/解决作用。第二个实验用功能性磁共振成像（fMRI）测试了这一想法，使用了条件性停止信号范式，从而能够检查冲突引起的减缓的行为和神经特征。preSMA，IFC和ESTA区域显着激活更大的冲突引起的放缓。激活强烈对应的DWI道分析预测的空间焦点，以及与完全反应抑制激活的焦点。这些结果说明了纤维束描记术如何揭示功能磁共振成像可验证的连接。研究结果还表明，右半球的三向功能解剖网络可以制动或完全停止反应。
The ability to stop motor responses depends critically on the right inferior frontal cortex (IFC) and also engages a midbrain region consistent with the subthalamic nucleus (STN). Here we used diffusion-weighted imaging (DWI) tractography to show that the IFC and the STN region are connected via a white matter tract, which could underlie a "hyperdirect" pathway for basal ganglia control. Using a novel method of "triangulation" analysis of tractography data, we also found that both the IFC and the STN region are connected with the presupplementary motor area (preSMA). We hypothesized that the preSMA could play a conflict detection/resolution role within a network between the preSMA, the IFC, and the STN region. A second experiment tested this idea with functional magnetic resonance imaging ( fMRI) using a conditional stop-signal paradigm, enabling examination of behavioral and neural signatures of conflict-induced slowing. The preSMA, IFC, and STN region were significantly activated the greater the conflict-induced slowing. Activation corresponded strongly with spatial foci predicted by the DWI tract analysis, as well as with foci activated by complete response inhibition. The results illustrate how tractography can reveal connections that are verifiable with fMRI. The results also demonstrate a three-way functional anatomical network in the right hemisphere that could either brake or completely stop responses.