Photoluminescence distinction of lung adenocarcinoma cells A549 and squamous cells H520 using metallothionein expression in response to Cd-doped Mn3[Co(CN)6]2 nanocubes
Photoluminescence distinction of lung adenocarcinoma cells A549 and squamous cells H520 using metallothionein expression in response to Cd-doped Mn3[Co(CN)6]2 nanocubes
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DOI：
10.1039/c6ra08370f
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发表时间：
2016-09
期刊：
影响因子：
3.9
通讯作者：
Jian Chen;Mengni He;Pengping Xu;Huihui Wu;Zhen Guo;Bingyang Shi;Qianwang Chen
中科院分区：
文献类型：
--
作者：
Jian Chen;Mengni He;Pengping Xu;Huihui Wu;Zhen Guo;Bingyang Shi;Qianwang Chen
Cd2+掺杂的发光Mn3[Co(CN)6]2纳米立方可以诱导人肺腺癌细胞A549产生比鳞状细胞H520更多的金属硫蛋白（MTs）。这些纳米立方体可以与mt结合，并被排除在细胞外进行解毒。那么A549细胞的荧光成像强度低于H520细胞，可以区分两种细胞。
Luminescent Mn3[Co(CN)6]2 nanocubes doped with Cd2+ can induce human lung adenocarcinoma cells A549 generating more metallothioneins (MTs) than squamous cells H520. The nanocubes can be bound to MTs and be excluded from cells for detoxification. Then A549 cells have a lower fluorescence imaging intensity than H520 cells, which can distinguish the two kinds of cells.