Social impulsivity inversely associated with CSF5-HIAA and fluoxetine exposure in vervet monkeys
Social impulsivity inversely associated with CSF5-HIAA and fluoxetine exposure in vervet monkeys
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DOI：
10.1016/s0893-133x(00)00211-6
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发表时间：
2001-04-01
影响因子：
7.6
通讯作者：
McGuire, MT
中科院分区：
文献类型：
--
作者：
Fairbanks, LA;Melega, WP;McGuire, MT
动物和人体研究表明，中枢5-羟色胺系统参与抑制冲动行为。两项研究旨在评估这种关系，在雄性长尾猴（Cercopithecus aethiops sabaeus）上升的标准化测试冲动的社会背景下：入侵者的挑战。在第一项研究中，对陌生成年男性入侵者的内在冲动（包括接近潜伏期和侵略性和自信的相互作用）与脑池脑脊液中5-羟色胺代谢物5-羟基吲哚乙酸（5-HIAA）的水平呈负相关（r =-0.33，p <0.01，n = 138）。冲动指数的接近性（而非攻击性）成分是这种关系的主要贡献者（部分r =-0.27，p <0.01）。第二个实验比较了在用氟西汀（2 mg/kg，i. m.）或车辆。氟西汀治疗组受试者（n = 6）的冲动指数评分显著低于对照组（n = 12）。这两项研究的结果为肾上腺素能对社会冲动性的影响提供了证据。(C)2001年美国神经精神病学学会。出版社：Elsevier Science Inc.
Animal and humnn research suggests that the central serotonin system is involved in the inhibition of impulsive behavior. Two studies were designed to assess this relationship in male vervet monkeys (Cercopithecus aethiops sabaeus) rising a standardized test of impulsivity in a social context: the Intruder Challenge. In the first study an inner of impulsivity in response to an unfamiliar adult male intruder (including latency to approach and aggressive and assertive interactions) was inversely correlated With levels of the serotonin metabolite, 5-hydroxyindoleacetic acid (5-HIAA) in cisternal cerebrospinal fluid (r = -0.33, p < .01, n = 138). The approach, but not aggressive, component of the Impulsivity Index runs the primary contributor to this relationship (partial r = -0.27, p < .01). The second experiment compared responses to the Intruder Challenger after 9 weeks of daily treatment with fluoxetine (2 mg/kg, i.m.) or vehicle. Fluoxetine-treated subjects (n = 6) had significantly lower Impulsivity Index scores than controls (n = 12). The results from these two investigations provide evidence for serotonergic influences on social impulsivity. (C) 2001 American College of Neuropsychopharmocology. Published by Elsevier Science Inc.