Handbook of Chemical Biology of Nucleic Acids

Handbook of Chemical Biology of Nucleic Acids
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核酸化学生物学手册

DOI:
10.1007/978-981-16-1313-5_97-1
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发表时间:
2022
期刊:
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影响因子:
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通讯作者:
Waller Z
Waller Z
中科院分区:
--
文献类型:
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作者:
Waller Z

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I基序是由富含胞嘧啶的序列形成的四链核酸二级结构,由半质子化的胞嘧啶-胞嘧啶碱基对稳定。在这一章中,我们将带你通过I-基序核酸的概述:I-基序DNA的结构,它们与pH的特殊关系,它们在生物学中的潜在功能,以及配体和探针的靶向。
i-Motifs are four-stranded nucleic acid secondary structures formed from sequences rich in cytosine and are stabilized by hemi-protonated cytosine–cytosine base pairs. In this chapter, we take you through an overview of i-motif nucleic acids: the structure of i-motif DNA, their special relationship with pH, their potential functions in biology, and targeting with ligands and probes.