Basigin expression as a prognostic indicator in stage I pulmonary adenocarcinoma
Basigin expression as a prognostic indicator in stage I pulmonary adenocarcinoma
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DOI：
10.1111/pin.12646
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发表时间：
2018-04
影响因子：
2.2
通讯作者：
Toshihide Matsumoto;R. Nagashio;S. Ryuge;S. Igawa;Makoto Kobayashi;E. Fukuda;N. Goshima;M. Ichinoe
中科院分区：
文献类型：
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作者：
Toshihide Matsumoto;R. Nagashio;S. Ryuge;S. Igawa;Makoto Kobayashi;E. Fukuda;N. Goshima;M. Ichinoe
我们使用肺癌细胞系作为抗原和随机免疫方法建立了KU‐Lu‐8单克隆抗体（MoAb）。KU‐Lu‐8单克隆抗体识别basigin（BSG），这是一种跨膜型糖蛋白，在肺癌细胞的细胞膜上强烈表达。本研究旨在探讨BSG在肺腺癌中的表达与临床病理参数之间的关系，以及BSG表达对肺腺癌患者预后的意义。为探讨BSG在肺癌中的表达意义，我们对113例手术切除的肺腺癌进行了免疫组化分析，并评估了BSG表达与各种临床病理参数之间的关系。Kaplan-Meier生存分析和考克斯比例风险模型用于研究BSG表达对生存的影响。在临床病理学上，BSG表达与肿瘤分化程度、血管浸润、淋巴管浸润和预后不良显著相关。特别是，BSG表达与I期AC患者的较差生存率显著相关。高BSG表达组（与低BSG表达组相比）显示校正后的死亡率风险比为4.694。BSG表达表明AC患者预后不良，特别是I期疾病患者。
We established the KU‐Lu‐8 monoclonal antibody (MoAb) using a lung cancer cell line as an antigen and a random immunization method. The KU‐Lu‐8 MoAb recognizes basigin (BSG), which is a transmembrane‐type glycoprotein that is strongly expressed on the cell membranes of lung cancer cells. This study aimed to clarify the relationships between BSG expression and clinicopathological parameters and determine the prognostic significance of BSG expression in pulmonary adenocarcinoma (AC) patients. To evaluate the significance of BSG expression in lung cancer, we immunohistochemically analyzed 113 surgically resected pulmonary adenocarcinomas, and the associations between BSG expression and various clinicopathological parameters were evaluated. Kaplan‐Meier survival analysis and Cox proportional hazards models were used to investigate the effects of BSG expression on survival. Clinicopathologically, BSG expression was significantly associated with tumor differentiation, vascular invasion, lymphatic invasion, and a poor prognosis. In particular, BSG expression was significantly correlated with poorer survival in patients with stage I AC. The high BSG expression group (compared with the low BSG expression group) exhibited adjusted hazard ratios for mortality of 4.694. BSG expression is indicative of a poor prognosis in AC patients, particularly in those with stage I disease.