Mediastinal benign epithelioid schwannoma: a rare tumor in an unreported location
Mediastinal benign epithelioid schwannoma: a rare tumor in an unreported location
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纵隔良性上皮样神经鞘瘤：一种罕见肿瘤，发生部位未报道
DOI：
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
林旭勇
中科院分区：
文献类型：
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作者：
张秀鹏;姜桂洋;王恩华;林旭勇
良性上皮样神经鞘瘤是神经鞘瘤的一种非常罕见的变体，可以构成诊断挑战。报告的病例主要位于真皮/皮下组织。虽然传统的神经鞘瘤发生在后纵膈腔很常见，但据我们所知，在英文文献中并无纵膈腔良性上皮样神经鞘瘤的报告。在此，我们提出一个50岁男性纵膈腔良性上皮样神经鞘瘤的病例。组织学上，肿瘤被包裹得很好，由上皮样肿瘤细胞组成，在纤维或粘液样间质中有轻度细胞浸润。免疫组化：肿瘤细胞S-100、GFAP、Vimentin阳性，细胞角蛋白、EMA、P63、Actin（SM）、CD_3、CD_（20）、CD_（30）、CD_（31）、CD_（34）、细胞角蛋白19、HMB_（45）、CD_（68）、Desmin阴性。Ki-67增殖指数约为0.2%。根据形态学特征和免疫组化染色，肿瘤被诊断为上皮样。神经鞘瘤。值得注意的是，上皮样神经鞘瘤也可能是纵隔肿瘤的重要鉴别诊断。diagnosis.in
Benign epithelioid schwannoma is a very rare variant of schwannoma, that can pose a diagnostic challenge..The reported cases were predominantly located in dermal/subcutaneous tissue. Although conventional.schwannoma occurring in the posterior mediastinum was common, to our knowledge, no mediastinal benign epithelioid.schwannoma was reported in English literature. Herein, we presented a case of mediastinal benign epithelioid.schwannoma in a 50-year-old Chinese male. Histologically, the tumor was well encapsulated and consisted of.sheets of epithelioid tumor cells with mild cellular atypia set in fibrous or myxoid stroma. Immunohistochemically,.the tumor cells were positive for S-100, GFAP and Vimentin, negative for cytokeratin, EMA, P63, Actin (SM), CD3,.CD20, CD30, CD31, CD34, cytokeratin19, HMB45, CD68 and Desmin. Ki-67 proliferation index was approximately.2%. Based on morphologic features and the immunohistochemical staining, the tumor was diagnosed as an epithelioid.schwannoma. It should be noted that epithelioid schwannoma may be also an important differential diagnosis.in mediastinal tumor.