Severity of leukoaraiosis and susceptibility to infarct growth in acute stroke
Severity of leukoaraiosis and susceptibility to infarct growth in acute stroke
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DOI：
10.1161/strokeaha.107.501932
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发表时间：
2008-05-01
期刊：
影响因子：
8.3
通讯作者：
Sorensen, A. Gregory
中科院分区：
文献类型：
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作者：
Ay, Hakan;Arsava, E. Murat;Sorensen, A. Gregory
背景和目的-脑白质疏松症（LA）与血管结构和功能变化有关，可能会损害微血管水平的组织灌注。我们假设 LA 的体积与急性人类中风中最初缺血但最终梗死的组织的比例相关。方法 - 我们研究了 61 名连续的弥散加权成像平均通过时间不匹配的患者。所有患者在症状出现后 12 小时内以及第 4 天和第 30 天之间接受两次扫描。我们探讨了急性图像上具有 LA 的白质区域的体积与进展为梗死的扩散加权成像平均传输时间不匹配组织的比例（失配丢失百分比）之间的关系。结果双变量分析显示，失配丢失百分比与 LA 体积之间存在统计显着相关性（r = 0.33，P
Background and Purpose-Leukoaraiosis (LA) is associated with structural and functional vascular changes that may compromise tissue perfusion at the microvascular level. We hypothesized that the volume of LA correlated with the proportion of initially ischemic but eventually infarcted tissue in acute human stroke.Methods-We studied 61 consecutive patients with diffusion-weighted imaging-mean transit time mismatch. All patients were scanned twice within 12 hours of symptom onset and between days 4 and 30. We explored the relationship between the volume of white matter regions with LA on acute images and the proportion of diffusion-weighted imaging-mean transit time mismatch tissue that progressed to infarction (percentage mismatch lost).Results-Bivariate analyses showed a statistically significant correlation between percentage mismatch lost and LA volume (r = 0.33, P