Vertical transmission of susceptibility to stuttering with sex-modified expression.
Vertical transmission of susceptibility to stuttering with sex-modified expression.
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性别修饰表达对口吃易感性的垂直传播。
DOI：
10.1073/pnas.78.1.606
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发表时间：
1981
影响因子：
11.1
通讯作者：
M. A. Records
中科院分区：
文献类型：
--
作者：
K. Kidd;R. Heimbuch;M. A. Records
口吃通常不被认为是遗传性的，尽管它长期以来一直被认为是家族性的。收集的数据对2035亲属的397无关的成年口吃者证实和量化的强大的家族浓度。我们的分析方法，这些家庭的数据，一个不需要规范的遗传假设，表明口吃的亲属之间发生的模式，表明垂直传输的易感性口吃与性别修饰的表达。虽然简单的孟德尔假说不足以解释在家族中观察到的口吃模式，但更复杂的遗传模型可以解释这种模式。在过去，这种证据被认为是充分的，因为它不排除文化传播的可能性。然而，这些数据排除了以前提出的某些文化传播假设。这项研究的发现支持了语言病理学家越来越多的观点，即大多数口吃是一种遗传性神经障碍。
Stuttering is not usually considered genetic, although it has long been known to be familial. Data collected on 2035 relatives of 397 unrelated adult stutterers confirm and quantify the strong familial concentration. Our analytic approach to these family data, one that does not require specification of a genetic hypothesis, shows that stuttering among relatives occurs in a pattern indicating vertical transmission of a susceptibility to stuttering with sex-modified expression. Although simple Mendelian hypotheses are not sufficient to explain the observed pattern of stuttering in families, more complex genetic models can explain the pattern. In the past, such evidence has been considered sufficient, because it does not preclude the possibility of cultural transmission. However, certain cultural transmission hypotheses previously proposed for stuttering are excluded by these data. The findings in this study support a growing opinion among speech pathologists that most stuttering is a genetically inherited neurologic disorder.