A Methylome-Wide Association Study of Trajectories of Oppositional Defiant Behaviors and Biological Overlap With Attention Deficit Hyperactivity Disorder.
A Methylome-Wide Association Study of Trajectories of Oppositional Defiant Behaviors and Biological Overlap With Attention Deficit Hyperactivity Disorder.
复制标题
DOI：
10.1111/cdev.12957
复制
发表时间：
2018-09
影响因子：
4.6
通讯作者：
Gaunt TR
中科院分区：
文献类型：
--
作者：
Barker ED;Walton E;Cecil CAM;Rowe R;Jaffee SR;Maughan B;O'Connor TG;Stringaris A;Meehan AJ;McArdle W;Relton CL;Gaunt TR
第671章母亲（49%男性）对流行病学出生队列，我们调查了（a）DNA甲基化之间的前瞻性关联（出生时）和轨迹（B）在ODD轨迹和注意缺陷多动障碍（ADHD）之间的由DNA甲基化索引的共同生物学途径;（c）对DNA甲基化的遗传影响;（d）产前风险暴露相关性。在甲基化组范围内，ODD和任性之间存在显著相关性，但与易怒无关。重叠分析表明ODD，任性和ADHD之间存在生物学相关性。ODD和任性的DNA甲基化（在一定程度上）受到遗传影响。DNA甲基化与母亲焦虑（任性）和吸烟（ODD和任性）的产前风险暴露相关。
In 671 mother–child (49% male) pairs from an epidemiological birth cohort, we investigated (a) prospective associations between DNA methylation (at birth) and trajectories (ages 7–13) of oppositional defiant disorder (ODD), and the ODD subdimensions of irritable and headstrong; (b) common biological pathways, indexed by DNA methylation, between ODD trajectories and attention deficit hyperactivity disorder (ADHD); (c) genetic influence on DNA methylation; and (d) prenatal risk exposure associations. Methylome‐wide significant associations were identified for the ODD and headstrong, but not for irritable. Overlap analysis indicated biological correlates between ODD, headstrong, and ADHD. DNA methylation in ODD and headstrong was (to a degree) genetically influenced. DNA methylation associated with prenatal risk exposures of maternal anxiety (headstrong) and cigarette smoking (ODD and headstrong).
登录
查看更多内容
影响因子：
6.8
作者：
Cecil CA;Walton E;Smith RG;Viding E;McCrory EJ;Relton CL;Suderman M;Pingault JB;McArdle W;Gaunt TR;Mill J;Barker ED
通讯作者：
Barker ED
DOI：
10.1111/j.2044-8341.1988.tb02787.x
发表时间：
1988-09-01
期刊：
BRITISH JOURNAL OF MEDICAL PSYCHOLOGY
影响因子：
--
作者：
BIRTCHNELL, J;EVANS, C;KENNARD, J
通讯作者：
KENNARD, J
影响因子：
12.3
作者：
Gaunt TR;Shihab HA;Hemani G;Min JL;Woodward G;Lyttleton O;Zheng J;Duggirala A;McArdle WL;Ho K;Ring SM;Evans DM;Davey Smith G;Relton CL
通讯作者：
Relton CL
影响因子：
3
作者：
Binder, Alexandra M.;Michels, Karin B.
通讯作者：
Michels, Karin B.
影响因子：
30.8
作者：
Berkel, Simone;Marshall, Christian R.;Rappold, Gudrun A.
通讯作者：
Rappold, Gudrun A.