Effects of Microglial Activation and Polarization on Brain Injury After Stroke.
Effects of Microglial Activation and Polarization on Brain Injury After Stroke.
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DOI：
10.3389/fneur.2021.620948
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发表时间：
2021
影响因子：
3.4
通讯作者：
Xu Z
中科院分区：
文献类型：
--
作者：
Dong R;Huang R;Wang J;Liu H;Xu Z
中风是全球最常见的死亡原因之一。神经炎症和脑水肿的后续发展显著增加了与中风相关的风险，导致死亡率大幅增加。虽然在改善脑卒中急性期脑灌注方面取得了相当大的进展，但与脑梗死相关的亚急性期和慢性期的有效治疗选择有限。小胶质细胞是中枢神经系统（CNS）的先天性免疫细胞，可被激活和极化以响应与中风相关的刺激而呈现不同的表型，包括促炎和抗炎表型，其影响中风的预后。因此，研究小胶质细胞的激活和极化机制在脑卒中的治疗中起着至关重要的作用。本文旨在通过总结小胶质细胞的激活、极化机制和一般特征，探讨小胶质细胞表型调控在卒中治疗中的意义。
Stroke is one of the most common causes of death worldwide. The subsequent development of neuroinflammation and brain edema dramatically increases the risks associated with stroke, leading to a substantial increase in mortality. Although considerable progress has been made in improving cerebral perfusion in the acute phase of stroke, effective treatment options for the subacute and chronic phases associated with cerebral infarction are limited. Microglia, the innate immune cells of the central nervous system (CNS), can be activated and polarized to take on different phenotypes in response to stimulations associated with stroke, including pro-inflammatory and anti-inflammatory phenotypes, which affect the prognosis of stroke. Therefore, investigation of the activation and polarizing mechanisms of microglia plays a critical role in treating stroke. The aim of this article was to investigate the significance of microglial phenotype regulation in stroke treatment by summarizing the activation, polarizing mechanisms, and general microglia characteristics.
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影响因子：
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作者：
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通讯作者：
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