Reproductive factors in the aetiology of breast cancer.
Reproductive factors in the aetiology of breast cancer.
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DOI：
10.1038/bjc.1983.128
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发表时间：
1983-06
影响因子：
8.8
通讯作者：
Fraumeni, J F Jr
中科院分区：
文献类型：
--
作者：
Brinton, L A;Hoover, R;Fraumeni, J F Jr
对通过多中心筛查项目确定的1 362例乳腺癌病例和1 250例对照进行了访谈研究，从而能够对乳腺癌的生殖决定因素进行评价。风险随着第一次活产的年龄线性增加; 30岁以后生育的妇女比18岁以前生育的妇女风险高4-5倍，而未经产的妇女的风险与第一次生育在20多岁的妇女相似。早期首次怀孕所提供的保护适用于以活产或死产结束的怀孕，但不适用于以其他结果终止的怀孕。在经产妇女中，除多次流产外，活产前妊娠早期流产与风险升高无关（RR = 2.2，95%CI 0.9-5.1）。虽然人数有限，但报告在没有活产的情况下进行人工流产的妇女的风险有所增加。第一次活产的年龄解释了大多数相关性，但对于多胎妇女和那些在早期生育过几次的妇女，风险仍有一定程度的降低。有证据表明，婚后推迟生育会增加风险，但这并不能解释与初次生育年龄晚相关的高风险。
An interview study of 1,362 breast cancer cases and 1,250 controls identified through a multi-centre screening project allowed an evaluation of reproductive determinants of breast cancer. Risk increased linearly with age at first livebirth; women with a birth after age 30 showed 4-5-fold excess risks compared to those with a birth prior to 18, while the risk for nulliparous women resembled that for women whose first birth was in their late twenties. The protection conferred by an early first pregnancy prevailed for pregnancies that ended in a livebirth or stillbirth, but not for those that terminated in other outcomes. Among parous women, a first trimester abortion prior to a livebirth was not associated with an elevated risk, except in the event of multiple miscarriages (RR = 2.2, 95% Cl 0.9-5.1). Although numbers were limited, women who reported an induced abortion in the absence of ever having a livebirth showed some elevation in risk. Age at first livebirth explained most associations, but some residual reduction in risk was noted for multiparous women and those with several births at an early age. There was evidence that delays in birth after marriage increased risk, but this did not explain the high risk associated with late age at first birth.