TCR triggering by the pMHC complex: valency, affinity, and dynamics.
TCR triggering by the pMHC complex: valency, affinity, and dynamics.
复制标题
由 pMHC 复合体触发的 TCR：效价、亲和力和动力学。
DOI：
10.1126/stke.119pe21
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发表时间：
2008
影响因子：
7.3
通讯作者：
Varma,Rajat
中科院分区：
文献类型：
--
作者：
Varma,Rajat
T细胞受体（TCR）和负载肽的主要组织相容性复合物（pMHC）之间的相互作用是免疫学中研究最多的相互作用之一，但该系统运作的确切机制仍不完全清楚。一个关键问题是TCR触发是否最低限度地需要单体pMHC复合物或高阶多聚体（两个或更多个pMHC）。任何TCR触发模型都必须解释这种受体系统所表现出的配体反应性的高灵敏度、特异性和动态范围。TCR触发的大多数模型尚未完全理解TCR触发的动态方面。TCR触发发生得非常快，敏感性和特异性的特性可以通过解释这种受体系统的相互作用动力学的模型来解释。在本文中，它提出了在TCR触发的重要参数是固定的TCR-pMHC复合物在质膜上。这是否涉及单体或多聚体pMHC可能取决于TCR对pMHC的亲和力。
The interaction between the T cell receptor (TCR) and a peptide-loaded major histocompatibility complex (pMHC) is one of the most-studied interactions in immunology, and yet the precise mechanism by which this system operates is still not fully understood. One key issue is whether TCR triggering minimally requires monomeric pMHC complexes or higher-order multimers (two or more pMHCs). Any model of TCR triggering must explain the high sensitivity, specificity, and dynamic range of ligand responsiveness that this receptor system exhibits. Most models of TCR triggering have not fully appreciated the dynamic aspects of TCR triggering. TCR triggering happens very quickly, and the properties of sensitivity and specificity can be explained by a model that accounts for the interaction dynamics of such a receptor system. In this paper, it is proposed that the important parameter in TCR triggering is the immobilization of the TCR-pMHC complex in the plasma membrane. Whether this involves monomeric or multimeric pMHCs may depend on the affinity of the TCR for the pMHC.