Mucin-Type O-Glycans: Barrier, Microbiota, and Immune Anchors in Inflammatory Bowel Disease.
Mucin-Type O-Glycans: Barrier, Microbiota, and Immune Anchors in Inflammatory Bowel Disease.
复制标题
粘液型O-葡聚糖：炎症性肠病中的屏障、微生物区系和免疫锚。
DOI：
10.2147/jir.s327609
复制
发表时间：
2021
影响因子：
4.5
通讯作者：
Xu Z
中科院分区：
文献类型：
--
作者：
Zhang Y;Wang L;Ocansey DKW;Wang B;Wang L;Xu Z
炎症性肠病（IBD）影响全球约700万人，是一种由肠道微生物群改变、免疫失调以及遗传和环境因素引起的胃肠道慢性炎症性疾病。黏液型o -聚糖与微生物和免疫分子的关系越来越受到研究者的关注。黏液蛋白是黏液的主要成分，在结肠中形成微生物群和免疫细胞之间的保护屏障。粘蛋白型o -聚糖改变胃肠道微生物的多样性，进而通过利用聚糖提高宿主肠道蛋白的o -糖基化水平。此外，粘蛋白型o -聚糖的改变不仅增加了免疫细胞的活性和稳定性，而且还参与了肠黏膜免疫耐受的维持。尽管越来越多的证据表明粘蛋白型o -聚糖在IBD中发挥重要作用，但整合现有数据的文献有限，无法全面了解o -聚糖如何影响IBD。本文就黏液型o -聚糖在IBD中的作用作一综述。这项研究旨在提供更好的理解，并鼓励未来对IBD糖基化的研究和设计新的糖基化IBD治疗方法。
Inflammatory bowel disease (IBD), which affects about 7 million people globally, is a chronic inflammatory condition of the gastrointestinal tract caused by gut microbiota alterations, immune dysregulation, and genetic and environmental factors. The association of microbial and immune molecules with mucin-type O-glycans has been increasingly noticed by researchers. Mucin is the main component of mucus, which forms a protective barrier between the microbiota and immune cells in the colon. Mucin-type O-glycans alter the diversity of gastrointestinal microorganisms, which in turn increases the level of O-glycosylation of host intestinal proteins via the utilization of glycans. Additionally, alterations in mucin-type O-glycans not only increase the activity and stability of immune cells but are also involved in the maintenance of intestinal mucosal immune tolerance. Although there is accumulating evidence indicating that mucin-type O-glycans play an important role in IBD, there is limited literature that integrates available data to present a complete picture of exactly how O-glycans affect IBD. This review emphasizes the roles of the mucin-type O-glycans in IBD. This seeks to provide a better understanding and encourages future studies on IBD glycosylation and the design of novel glycan-inspired therapies for IBD.