Noradrenergic modulation of behavioral odor detection and discrimination thresholds in the olfactory bulb
Noradrenergic modulation of behavioral odor detection and discrimination thresholds in the olfactory bulb
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DOI：
10.1111/j.1460-9568.2010.07297.x
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发表时间：
2010-08-01
影响因子：
3.4
通讯作者：
Linster, Christiane
中科院分区：
文献类型：
--
作者：
Escanilla, Olga;Arrellanos, Adolfo;Linster, Christiane
哺乳动物的主嗅球（MOB）从蓝斑接受重要的去甲肾上腺素能输入。去甲肾上腺素（NE）参与新生动物条件性气味偏好的获得和某些种属特异性气味依赖行为。到目前为止，NE在成年大鼠气味加工中的作用仍然很少研究。我们研究的作用，去甲肾上腺素能调制的MOB气味检测和歧视阈值，使用行为和计算建模方法。成年大鼠双侧MOB注射溶媒、NE（0.1-1000 μ m）、去甲肾上腺素能受体拮抗剂和NE +受体拮抗剂。NE输注改善了作为NE和气味浓度的函数的气味检测和辨别。在任何给定的气味浓度的NE的检测和歧视幅度的影响变化在一个非线性函数相对于NE浓度。受体拮抗剂输注表明，α 1受体激活是必要的NE的调节作用。计算模型表明，α 1受体激活强度的增加导致改善的气味信噪比和尖峰同步的二尖瓣细胞，可能是行为观察到的检测和辨别阈值下降的基础。我们的研究结果是第一次表明，NE或去甲肾上腺素能受体拮抗剂直接注入到初级感觉网络调制感官检测和歧视阈值在非常低的刺激浓度。
The mammalian main olfactory bulb (MOB) receives a significant noradrenergic input from the locus coeruleus. Norepinephrine (NE) is involved in the acquisition of conditioned odor preferences in neonatal animals and in some species-specific odor-dependent behaviors. Thus far, the role of NE in odor processing in adult rats remains less studied. We investigated the role of noradrenergic modulation in the MOB on odor detection and discrimination thresholds using behavioral and computational modeling approaches. Adult rats received bilateral MOB injections of vehicle, NE (0.1-1000 mu m), noradrenergic receptor antagonists and NE + receptor antagonists combined. NE infusion improved odor detection and discrimination as a function of NE and odor concentration. The effect of NE on detection and discrimination magnitude at any given odor concentration varied in a non-linear function with respect to NE concentration. Receptor antagonist infusion demonstrated that alpha 1 receptor activation is necessary for the modulatory effect of NE. Computational modeling showed that increases in the strength of alpha 1 receptor activation leads to improved odor signal-to-noise ratio and spike synchronization in mitral cells that may underlie the behaviorally observed decrease of detection and discrimination thresholds. Our results are the first to show that direct infusion of NE or noradrenergic receptor antagonists into a primary sensory network modulates sensory detection and discrimination thresholds at very low stimulus concentrations.