Subthalamic nucleus deep brain stimulus evoked potentials:: Physiological and therapeutic implications
Subthalamic nucleus deep brain stimulus evoked potentials:: Physiological and therapeutic implications
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DOI：
10.1002/mds.10206
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发表时间：
2002-09-01
影响因子：
8.6
通讯作者：
Lüders, HO
中科院分区：
文献类型：
--
作者：
Baker, KB;Montgomery, EB;Lüders, HO
本文观察了10例帕金森病和4例癫痫患者的丘脑底核电刺激对皮层脑电活动的影响。诱发电位是通过时间锁定脑电描记术产生的，以通过植入先前接受过深部脑刺激（DBS）手术的患者体内的电极导线输送电刺激的开始。探讨了不同刺激模式对诱发反应的影响，包括单脉冲和双脉冲以及突发刺激。皮层诱发电位的单脉冲，观察到与lavelation短至1至2毫秒后，一个单一的脉冲刺激，与活动持续，在某些情况下，高达400毫秒。配对脉冲实验揭示了约0.5毫秒的不应期，这表明轴突的刺激有助于产生至少一部分的诱发电位波形。对100毫秒的刺激爆发也存在诱发电位，有一些证据表明该电位是在爆发伪影内启动的。观察到的响应类型以及潜在的应用程序的潜在影响进行了讨论。(C)2002运动障碍协会。
The effect of subthalamic nucleus (STN) stimulation on cortical electroencephalographic activity was examined in 10 patients with Parkinson's disease and 4 patients with epilepsy. Evoked potentials were created by time-locking electroencephalography to the onset of electrical stimulation delivered through the lead implanted in the STN of patients who had previously undergone deep brain stimulation (DBS) surgery. The effect of different patterns of stimulation on the evoked response, including single- and paired-pulse as well as burst stimulation, was explored. Cortical evoked potentials to single pulses were observed with latencies as short as 1 to 2 msec after a single pulse of stimulation, with activity continuing, in some cases, for up to 400 msec. Paired-pulse experiments revealed refractory periods on the order of 0.5 msec, suggesting that stimulation of axons contributed to the generation of at least some portion of the evoked potential waveform. Evoked potentials were also present in response to 100-msec bursts of stimulation, with some evidence that the potential was initiated within the burst artifact. The potential implications of the types of responses observed as well as potential applications are discussed. (C) 2002 Movement Disorder Society.