Hereditary colorectal cancer: keeping it in the family - the bowel cancer story
Hereditary colorectal cancer: keeping it in the family - the bowel cancer story
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DOI：
10.1046/j.1445-5994.2002.00224.x
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发表时间：
2002-07-01
影响因子：
2.1
通讯作者：
Spigelman, AD
中科院分区：
文献类型：
--
作者：
McGrath, DR;Spigelman, AD
高达 20% 的结直肠癌被认为具有遗传成分。已知几种家族综合症会增加结直肠癌的风险。我们对这些综合征的认识不断进步，改善了对这些患者的护理，并提高了患者的总体生存率。基因检测在进一步改进检测和指导后续预防措施方面具有巨大潜力。与一些更常见的综合征相关的诊断、管理和监测问题 - 特别是家族性腺瘤性息肉病和遗传性非息肉病性结直肠癌 - 进行了回顾。
Up to 20% of colorectal cancers are thought to have a genetic component. Several familial syndromes are known to confer an increased risk for colorectal cancer. Advances in our understanding of these syndromes has impoved the care delivered to, and the overall survival of, these patients. Genetic testing has great potential to further improve detection and direct subsequent preventative measures. The diagnosis, management and surveillance issues relating to some of the more commonly encountered syndromes - in particular Familial Adenomatous Polyposis and Hereditary Non-Polyposis Colorectral Cancer - are reviewed.