MiR-126-5p regulates osteoclast differentiation and bone resorption in giant cell tumor through inhibition of MMP-13
MiR-126-5p regulates osteoclast differentiation and bone resorption in giant cell tumor through inhibition of MMP-13
复制标题
MiR-126-5p 通过抑制 MMP-13 调节巨细胞瘤中的破骨细胞分化和骨吸收。
DOI：
10.1016/j.bbrc.2013.12.075
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发表时间：
2014-01-17
影响因子：
3.1
通讯作者：
Xiao, Jianru
中科院分区：
文献类型：
--
作者：
Wu, Zhipeng;Yin, Huabin;Xiao, Jianru
骨巨细胞瘤是一种以骨吸收为特征的侵袭性骨肿瘤。基质金属蛋白酶-13（MMP-13）是骨巨细胞瘤基质细胞（GCTSCs）表达的主要蛋白酶，在骨巨细胞瘤溶骨性病变的形成中起重要作用。然而，MMP-13在GCTSCs中的表达调控的确切机制尚不清楚。在这项研究中，我们发现miR-126- 5 p在GCTSCs中显著下调，并通过在转录后水平抑制MMP-13表达来影响破骨细胞（OC）分化和骨吸收。因此，我们的研究表明，miR-126- 5 p在GCT的多核巨细胞形成和溶骨性病变中发挥重要的生理作用。(C)2013 Elsevier Inc. All rights reserved.
Giant cell tumor (GCT) of bone is an aggressive skeletal tumor characterized by localized bone resorption. Matrix metalloproteinase-13 (MMP-13) is the principal proteinase expressed by the stromal cells of GCT (GCTSCs) and also considered to play a crucial role in formation of the osteolytic lesion in GCT. However, the exact mechanism of the regulation of MMP-13 expression in GCTSCs was unknown. In this study, we identified miR-126-5p was significantly downregulated in GCTSCs and affect osteoclast (OC) differentiation and bone resorption by repressing MMP-13 expression at the post-transcriptional level. Thus, our studies show that miR-126-5p plays an important physiological role in multinucleated giant cell formation and osteolytic lesion in GCT. (C) 2013 Elsevier Inc. All rights reserved.