Effect of taurine on biomarkers of oxidative stress in tissues of fructose-fed insulin-resistant rats.
Effect of taurine on biomarkers of oxidative stress in tissues of fructose-fed insulin-resistant rats.
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发表时间：
2005-02
影响因子：
2.7
通讯作者：
A. Nandhini;V. Thirunavukkarasu;M. Ravichandran;C. Anuradha
中科院分区：
文献类型：
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作者：
A. Nandhini;V. Thirunavukkarasu;M. Ravichandran;C. Anuradha
引言本研究旨在探讨牛磺酸是否减轻果糖诱导的氧化应激大鼠组织，如心脏和肾脏。方法雄性Wistar大鼠，体重170-190 g，随机分为4组，每组6只。对照组动物接受含有淀粉的对照饮食，而果糖喂养的动物接受富含果糖的饮食（超过总热量的60%）。果糖和牛磺酸大鼠接受果糖饮食和2%牛磺酸溶液饮用。对照组和牛磺酸组大鼠接受对照饲料和2%牛磺酸溶液。治疗30天后，用稳态模型评估法（HOMA）测定胰岛素抵抗指数。检测心、肾组织脂质过氧化指标、酶和非酶抗氧化剂水平。结果果糖组大鼠HOMA值升高，脂质过氧化反应增强，抗氧化能力下降。牛磺酸治疗果糖大鼠减弱了脂质过氧化反应的增加，提高了抗氧化剂的水平，改善了胰岛素敏感性。结论牛磺酸可抑制大鼠组织中的过氧化反应，上调抗氧化活性，提示牛磺酸可作为胰岛素抵抗的辅助治疗药物。
INTRODUCTION The present study was designed to investigate whether taurine mitigates fructose-induced oxidative stress in rat tissues such as heart and kidney. METHODS Male Wistar rats of body weight 170-190 g were divided into four groups containing six rats each. Control animals received the control diet containing starch while fructose-fed animals received a fructose-enriched diet (greater than 60 percent of total calories). Fructose and taurine rats received the fructose diet and two percent taurine solution to drink. Control and taurine rats received the control diet and two percent taurine solution. After the treatment period of 30 days, insulin resistance index, by homeostasis model assessment (HOMA) was determined. The levels of lipid peroxidation markers, the enzymatic and non-enzymatic antioxidants status in heart and kidney tissues were measured. RESULTS Fructose rats showed high values of HOMA, increased lipid peroxidation and impaired antioxidant status. Taurine treatment to fructose rats attenuated the increased lipid peroxidation, enhanced the levels of antioxidants and improved insulin sensitivity. CONCLUSION Inhibition of peroxidation markers and upregulation of antioxidant activity in rat tissues by taurine signify the potential utility of taurine as an adjunct in treatment of insulin resistance.