Phospholipase C.

Phospholipase C.
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DOI:
10.1007/978-3-030-12457-1_9
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发表时间:
2020
影响因子:
--
通讯作者:
Vines CM
Vines CM
中科院分区:
医学4区
文献类型:
--
作者:
Bill CA;Vines CM

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磷脂酶C(PLC)家族成员构成了一个不同的酶家族。13个不同的家庭成员被克隆。这些家族成员具有介导各种功能的独特结构。虽然PLC家族成员似乎都通过裂解磷脂的双产物发出信号,但很明显,每个家族成员,有时每个亚型,都有助于独特的细胞功能。本章提供了一个关于PLC的现有文献综述。此外,还提供了关于未讨论的领域(包括PLC的酪氨酸激酶激活)的更深入信息的参考文献。了解单个PLC酶的作用及其独特的细胞功能,将有助于更好地了解这些酶在疾病发展和维持稳态中的生理作用。
Phospholipase C (PLC) family members constitute a family of diverse enzymes. Thirteen different family members have been cloned. These family members have unique structures that mediate various functions. Although PLC family members all appear to signal through the bi-products of cleaving phospholipids, it is clear that each family member, and at times each isoform, contributes to unique cellular functions. This chapter provides a review of the current literature on PLC. In addition, references have been provided for more in-depth information regarding areas that are not discussed including tyrosine kinase activation of PLC. Understanding the roles of the individual PLC enzymes, and their distinct cellular functions, will lead to a better understanding of the physiological roles of these enzymes in the development of diseases and the maintenance of homeostasis.
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