Testosterone and trenbolone enanthate increase mature myostatin protein expression despite increasing skeletal muscle hypertrophy and satellite cell number in rodent muscle
Testosterone and trenbolone enanthate increase mature myostatin protein expression despite increasing skeletal muscle hypertrophy and satellite cell number in rodent muscle
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DOI：
10.1111/and.12622
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发表时间：
2017-04-01
期刊：
影响因子：
2.4
通讯作者：
Beck, D. T.
中科院分区：
文献类型：
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作者：
Dalbo, V. J.;Roberts, M. D.;Beck, D. T.
雄性激素诱导的成年啮齿类动物骨骼肌纤维横截面积（fCSA）、卫星细胞含量和肌肉生长抑制素（MSTs）的变化在10月龄的Fisher 344大鼠（n=41）中进行了检查，这些大鼠被分配到假手术、睾丸切除术（ORX）、ORX+睾酮（TEST; 7.0mg周（-1））或ORX+群勃龙（TREN; 1.0mg周（-1））。29天后，对动物实施安乐死，并收获提肛肌/球海绵体肌（LABC）肌肉复合体用于分析。与ORX相比，ORX+TEST和ORX+TREN组LABC肌肉fCSA分别高出102%和94%（p
The androgen-induced alterations in adult rodent skeletal muscle fibre cross-sectional area (fCSA), satellite cell content and myostatin (Mstn) were examined in 10-month-old Fisher 344 rats (n=41) assigned to Sham surgery, orchiectomy (ORX), ORX+testosterone (TEST; 7.0mgweek(-1)) or ORX+trenbolone (TREN; 1.0mgweek(-1)). After 29days, animals were euthanised and the levator ani/bulbocavernosus (LABC) muscle complex was harvested for analyses. LABC muscle fCSA was 102% and 94% higher in ORX+TEST and ORX+TREN compared to ORX (p