Blood lactate is an important energy source for the human brain
Blood lactate is an important energy source for the human brain
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DOI：
10.1038/jcbfm.2009.35
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发表时间：
2009-06-01
影响因子：
6.3
通讯作者：
Nielsen, Henning B.
中科院分区：
文献类型：
--
作者：
van Hall, Gerrit;Stromstad, Morten;Nielsen, Henning B.
乳酸盐是大脑的潜在能量来源。本研究的目的是确定全身乳酸盐是否是大脑能量来源。我们测量了在体内脑乳酸动力学和氧化率在6个健康人在休息和没有90分钟的静脉乳酸输液（36 μ mol/kg bw/min），并在75%最大摄氧量的30分钟自行车运动期间，同时继续输注乳酸盐，以建立0.89 +/- 0.08的动脉乳酸盐浓度，分别为3.9 +/- 0.3和6.9 +/- 1.3 mmol/L。静息时，脑乳酸利用率从0.06 +/- 0.01的净乳酸释放变为乳酸输注期间的0.16 +/- 0.07 mmol/min的摄取，同时净葡萄糖摄取减少。运动期间，脑乳酸净摄取进一步增加至0.28 +/- 0.16 mmol/min。脑[1-C-13]乳酸摄取的大多数C-13标记物以（CO2）-C-13形式释放，在休息时和运动期间，分别为100% +/-24%、86% +/-15%和87% +/- 30%。在相应条件下，全身乳酸对脑能量消耗的贡献分别为8% +/-2%、19% +/-4%和27% +/- 4%。总之，全身乳酸被人脑吸收和氧化，是基础和高乳酸血症条件下大脑的重要底物。Journal of Cerebral Blood Flow & Metabolism（2009）29，1121-1129; doi：10.1038/jcbfm. 2009.35; 2009年4月1日在线发布
Lactate is a potential energy source for the brain. The aim of this study was to establish whether systemic lactate is a brain energy source. We measured in vivo cerebral lactate kinetics and oxidation rates in 6 healthy individuals at rest with and without 90 mins of intravenous lactate infusion ( 36 mu mol per kg bw per min), and during 30 mins of cycling exercise at 75% of maximal oxygen uptake while the lactate infusion continued to establish arterial lactate concentrations of 0.89 +/- 0.08, 3.9 +/- 0.3, and 6.9 +/- 1.3 mmol/L, respectively. At rest, cerebral lactate utilization changed from a net lactate release of 0.06 +/- 0.01 to an uptake of 0.16 +/- 0.07 mmol/min during lactate infusion, with a concomitant decrease in the net glucose uptake. During exercise, the net cerebral lactate uptake was further increased to 0.28 +/- 0.16 mmol/min. Most C-13-label from cerebral [1-C-13] lactate uptake was released as (CO2)-C-13 with 100% +/- 24%, 86% +/- 15%, and 87% +/- 30% at rest with and without lactate infusion and during exercise, respectively. The contribution of systemic lactate to cerebral energy expenditure was 8% +/- 2%, 19% +/- 4%, and 27% +/- 4% for the respective conditions. In conclusion, systemic lactate is taken up and oxidized by the human brain and is an important substrate for the brain both under basal and hyperlactatemic conditions. Journal of Cerebral Blood Flow & Metabolism (2009) 29, 1121-1129; doi:10.1038/jcbfm. 2009.35; published online 1 April 2009