Paclitaxel-Potentiated Photodynamic Theranostics for Synergistic Tumor Ablation and Precise Anticancer Efficacy Monitoring
Paclitaxel-Potentiated Photodynamic Theranostics for Synergistic Tumor Ablation and Precise Anticancer Efficacy Monitoring
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紫杉醇增强光动力治疗用于协同肿瘤消融和精确抗癌疗效监测
DOI：
10.1021/acsami.9b19073
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发表时间：
2020-02-05
影响因子：
9.5
通讯作者：
Luo，Liang
中科院分区：
文献类型：
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作者：
Wang，Xiuxia;Tong，Junwei;Luo，Liang
光动力疗法可以同时进行光动力疗法(PDT)和精确的治疗反应报告，已成为精密医学发展的一个有趣的方向。本文开发了一种超高效光动力治疗平台，该平台基于将治疗光敏剂TPCI与其他治疗方法相结合并增强，以实现协同抗癌效果和同步自我报告治疗反应。在本研究中，将TPCI与化疗药物紫杉醇(PTX)共包裹在脂质体中，对一系列肿瘤细胞株显示出极好的协同抗癌作用。与单纯的光动力疗法或化疗相比，这两种药物的效力都提高了30倍。更引人注目的是，释放的TPCI通过与染色质结合并激活其聚集诱导的发射，照亮了由PDT或化疗触发的死亡细胞的细胞核，从而实时自我报告了联合治疗的抗癌效果。使用PC3前列腺肿瘤细胞的小鼠模型进行的体内研究表明，TPCI/PTX@Lipo可以有效地消融初始尺寸为200 mm 3的肿瘤，并精确监测早期肿瘤反应。这种PTX增强的光动力治疗策略在这里代表了用于精确肿瘤治疗的自我报告纳米医学的新原型。
Photodynamic theranostics that allows for concurrent photodynamic therapy (PDT) and precise therapeutic response report has emerged as an intriguing direction in the development of precision medicine. An ultra-efficient photodynamic theranostics platform was developed here based on combining and potentiating a theranostic photosensitizer, TPCI, with other therapies for synergistic anticancer effect and synchronous self-reporting of therapeutic response. In this study, TPCI and a chemotherapy agent paclitaxel (PTX) were co-encapsulated in liposomes, which exhibited a superb synergistic anticancer effect against a series of tumor cell lines. The potency of both drugs had been boosted for up to 30-fold compared with sole PDT or chemotherapy. More strikingly, the released TPCI lighted up the nuclei of dead cells, triggered either by PDT or chemotherapy, through binding with the chromatin and activating its aggregation-induced emission, therefore self-reporting the anticancer effect of the combined therapy in real time. The in vivo study using a mouse model bearing PC3 prostate tumor cells demonstrated the effective ablation of tumors with initial sizes of 200 mm3and the precise early tumor response monitoring by TPCI/PTX@Lipo. This PTX-potentiated photodynamic theranostics strategy herein represented a new prototype of self-reporting nanomedicine for precise tumor therapy.