Respiratory cycle timing and fast inspiratory discharge rhythms in the adult decerebrate rat.
Respiratory cycle timing and fast inspiratory discharge rhythms in the adult decerebrate rat.
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成年去大脑大鼠的呼吸周期计时和快速吸气放电节律。
DOI：
10.1152/ajpregu.00117.2002
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Cohen,MortonI
中科院分区：
文献类型：
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作者：
Marchenko,Vitaliy;Granata,AntonioR;Cohen,MortonI
在丘上去脑瘫痪的成年大鼠，神经呼吸监测双侧膈记录。在呼吸周期定时的研究中，迷走神经传入输入的影响（肺充气）对呼吸相持续时间的影响与去大脑猫相似。1）在神经吸气（I）期间停止肺充气使I相持续时间延长46%（平均值，n= 11）。2）在神经呼气（E）期间维持肺充气使E期持续时间延长112%（平均值，n= 4）。在吸气放电快节律研究中，对16只大鼠的膈神经自频谱和双侧膈神经相干性进行了研究，结果显示两种快节律：高频振荡（HFO），有明显的相干峰（n= 9，范围106-160 Hz，平均132 Hz）;中频振荡（MFO），有自频谱峰，但无明显的相干峰（n= 11，范围46-96 Hz，平均66 Hz）。这些节律类似于去大脑猫的MFO和HFO，但模态频率范围大约是去大脑猫的两倍。此外，这些频率值与早期新生儿体外制剂研究中发现的20-40 Hz节律明显不同;差异可能是由于发育不成熟。
In supracollicular decerebrate paralyzed adult rats, neural respiration was monitored by bilateral phrenic recordings. In the study of respiratory cycle timing, the effects of vagal afferent input (lung inflation) on respiratory phase durations resembled those seen in decerebrate cats.1) Withholding lung inflation during neural inspiration (I) produced lengthening of I phase duration by 46% (mean,n= 11).2) Maintaining lung inflation during neural expiration (E) produced lengthening of E phase duration by 112% (mean,n= 4). In the study of fast rhythms in inspiratory discharges, phrenic nerve autospectra and bilateral (left-right) phrenic coherences in 16 rats revealed two types of fast rhythm:1) high-frequency oscillation (HFO), which had significant coherence peaks (n= 9, range 106–160 Hz, mean 132 Hz); and2) medium-frequency oscillation (MFO), which had autospectral peaks but no distinct coherence peaks (n= 11, range 46–96 Hz, mean 66 Hz). These rhythms resembled MFOs and HFOs in the decerebrate cat, but the modal frequency range was about twice as large. In addition, these frequency values differed markedly from the 20–40 Hz of the rhythms found in earlier studies in neonatal in vitro preparations; the difference may be due to developmental immaturity.