Association of aging with gene expression profiling in mouse submandibular glands.
Association of aging with gene expression profiling in mouse submandibular glands.
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DOI：
10.1016/j.gdata.2015.05.012
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发表时间：
2015-09
期刊：
影响因子：
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通讯作者：
Kamijo R
中科院分区：
文献类型：
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作者：
Saito Y;Yamada A;Suzuki D;Tanaka J;Nagahama R;Kurosawa T;Maki K;Mishima K;Shirota T;Kamijo R
衰老，也称为衰老，被认为是一种常见于各种器官和组织的生理现象（Enoki et al., 2007）。许多老年人的唾液腺功能障碍，例如口干症，其定义为由于唾液流量减少或缺失而导致的口干（Nagler 等，2004）。在本研究中，我们研究了年轻（8 周大）和成年（50 周大）小鼠颌下腺的基因表达，以分析衰老与小鼠颌下腺基因表达谱的关联。使用带有 Mouse-WG-6 v.2 Expression BeadChips (Illumina) 的 Illumina Sentrix 系统分析全基因组基因表达谱。在筛选的基因中，284 个基因的检测值显着性水平为 P < 0.01。其中，与年轻小鼠相比，成年小鼠中有 94 个基因（33%）的表达下降幅度更大。另一方面，190 个基因（77%）在成年小鼠中比幼年小鼠中增加更多。本研究获得的数据可在基因表达综合 (GEO) 数据库中公开获取（登录号 GSE66857）。
Aging, also called senescence, is thought to be a physiological phenomenon that commonly occurs in various organs and tissues (Enoki et al., 2007). Many older adults experience dysfunction in their salivary glands, for example xerostomia, which is defined as dry mouth resulting from reduced or absent saliva flow (Nagler et al., 2004). In the present study, we investigated gene expression in submandibular glands of young (8 weeks old) and adult (50 weeks old) mice to analyze association of aging with gene expression profiling in mouse submandibular glands. Whole-genome gene expression profiles were analyzed using an Illumina Sentrix system with Mouse-WG-6 v.2 Expression BeadChips (Illumina). Of the genes screened, 284 showed detection values at a significance level of P < 0.01. Among those, the expression of 94 genes (33%) showed a greater decrease in adult mice as compared to young mice. On the other hand, that of 190 genes (77%) was increased in the adults more than in young mice. The data obtained in this study are publicly available in the Gene Expression Omnibus (GEO) database (accession number GSE66857).