Social conflict models: Can they inform us about human psychopathology?
Social conflict models: Can they inform us about human psychopathology?
复制标题
DOI：
10.1016/j.yhbeh.2006.06.022
复制
发表时间：
2006-11-01
影响因子：
3.5
通讯作者：
Huhman, Kim L.
中科院分区：
文献类型：
--
作者：
Huhman, Kim L.
社会冲突模型被认为是研究大脑和行为如何被社会经验改变的基本问题的有力方法。特别是社会失败，似乎是大多数物种的主要压力源，在人类中，这种压力源被认为在各种精神疾病的发病中起重要作用，包括抑郁症和创伤后应激障碍。另一方面，攻击性经历可能会促进涉及不适当的攻击和暴力的疾病。目前使用社会冲突动物模型的研究涉及从遗传和分子到系统和公开行为的多层次分析。这篇综述简要地探讨了各种各样的这些动物模型的社会冲突，以评估它们是否是有用的，以促进我们的理解经验如何可以塑造大脑和行为，并翻译这些信息，使我们有可能提高生活质量的个人与精神疾病和行为障碍。(c)2006年爱思唯尔公司All rights reserved.
Social conflict models have been proposed as a powerful way to investigate basic questions of how brain and behavior are altered by social experience. Social defeat, in particular, appears to be a major stressor for most species, and in humans, this stressor is thought to play an important role in the onset of a variety of psychiatric disorders including depression and post-traumatic stress disorder. Aggressive experience, on the other hand, may promote disorders involving inappropriate aggression and violence. Current research using animal models of social conflict involves multiple levels of analysis from genetic and molecular to systems and overt behavior. This review briefly examines a variety of these animal models of social conflict in order to assess whether they are useful for advancing our understanding of how experience can shape brain and behavior and for translating this information so that we have the potential to improve the quality of life of individuals with mental illness and behavioral disorders. (c) 2006 Elsevier Inc. All rights reserved.