Linear morphea following Blaschko’ line with epidermal downmodulation of friend leukemia integration 1 transcription factor.
Linear morphea following Blaschko’ line with epidermal downmodulation of friend leukemia integration 1 transcription factor.
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Blaschko’系后的线性硬斑病，伴有友型白血病整合 1 转录因子的表皮下调。
DOI：
10.1111/ijd.16260
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发表时间：
2022
期刊：
影响因子：
3.6
通讯作者：
Satoh T
中科院分区：
文献类型：
--
作者：
Hashimoto T;Shinada Y;Okuzawa M;Satoh T
此外，在LM病变的表皮角质形成细胞和真皮成纤维细胞中观察到Friend白血病整合1转录因子（Fli-1）（一种抗纤维化因子，已知在硬皮病病变中下调）2的核表达缺失;这可能解释了遵循Blaschko线的机制。线状硬斑病（LM），也称为线状硬皮病，是硬斑病（局限性硬皮病）的一种变体，其中皮肤硬化病变遵循Blaschko线。1本文报告一例妊娠期发生抗单链DNA抗体（Ab）阳性的LM。患者在妊娠期间发生LM，抗ssDNA抗体呈阳性结果。国际皮肤病学杂志的版权是Wiley-Blackwell的财产，未经版权保持器的明确书面许可，其内容不得复制或通过电子邮件发送到多个网站或发布到列表服务器。但是，用户可以打印，下载或电子邮件的文章供个人使用。这篇摘要可以删节。不保证副本的准确性。用户应参考原始出版版本的材料的完整摘要。版权适用于所有摘要。
In addition, loss of nuclear expression of friend leukemia integration 1 transcription factor (Fli-1), an antifibrotic factor, known to be downmodulated in scleroderma lesions, 2 was observed in the epidermal keratinocytes and dermal fibroblasts in the LM lesion; this may explain the mechanisms for following Blaschko's line. Linear morphea (LM), also known as linear scleroderma, is a variant of morphea (localized scleroderma) in which sclerotic skin lesions follow Blaschko's line. 1 Here we report a case of LM with anti-single-stranded DNA (ssDNA) antibody (Ab), which occurred during her pregnancy. The patient developed LM during her pregnancy and showed a positive result for anti-ssDNA Ab.[Extracted from the article]Copyright of International Journal of Dermatology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. Copyright applies to all Abstracts.