Cancer Cells Employ the Most Prolific RNA Editors: A Closer Look at the Single-Cell Level.
Cancer Cells Employ the Most Prolific RNA Editors: A Closer Look at the Single-Cell Level.
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DOI：
10.1158/0008-5472.can-22-3537
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发表时间：
2023-02
期刊：
影响因子：
11.2
通讯作者：
Yikai Luo;Han Liang
中科院分区：
文献类型：
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作者：
Yikai Luo;Han Liang
腺苷到肌苷（A-to-I）RNA编辑是核苷酸多样化的主要来源，其在癌症进展和治疗反应中具有显著的机制意义。然而，它的活性和患病率尚未在单细胞分辨率下系统地确定。Chan及其同事通过对公共肺腺癌单细胞转录组数据集的深入分析，揭示了单个癌细胞中广泛的A-to-I RNA编辑事件。与其他细胞类型相比，在癌细胞中显著富集的编辑具有抑制先天免疫应答并预测用靶向疗法治疗的患者的不良治疗应答和预后的潜力。请参阅Chan等人的相关文章，第374页。
Adenosine-to-inosine (A-to-I) RNA editing is a major source of nucleotide diversification that has significant mechanistic implications in cancer progression and treatment response. However, its activity and prevalence have not yet been systematically determined at a single-cell resolution. Chan and colleagues revealed widespread A-to-I RNA editing events in single cancer cells through an in-depth analysis of a public lung adenocarcinoma single-cell transcriptome dataset. Edits significantly enriched in cancer cells compared to other cell types have the potential to inhibit innate immune response and to predict poor therapeutic response and prognosis in patients treated with targeted therapies. See related article by Chan et al., p. 374.