RHINOVIRUS UPPER RESPIRATORY-INFECTION INCREASES AIRWAY HYPERREACTIVITY AND LATE ASTHMATIC REACTIONS
RHINOVIRUS UPPER RESPIRATORY-INFECTION INCREASES AIRWAY HYPERREACTIVITY AND LATE ASTHMATIC REACTIONS
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DOI：
10.1172/jci113843
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发表时间：
1989-01-01
影响因子：
15.9
通讯作者：
BUSSE, WW
中科院分区：
文献类型：
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作者：
LEMANSKE, RF;DICK, EC;BUSSE, WW
虽然病毒性上呼吸道感染(URI)在许多哮喘患者中会引起喘息，但这些疾病对吸入抗原的呼吸道反应的影响尚未确定。下面的研究评估了一种实验性鼻病毒(RV)病对10名成年豚草变应性鼻炎患者的呼吸道反应性和对抗原的反应的影响。感染前研究包括测量呼吸道对组胺和豚草抗原的反应性。此外，还评估了患者对抗原的迟发性哮喘反应(LAR)(第一秒.apprx的用力呼气量减少15%)。抗原攻击后6h)。基线研究后1个月，患者鼻内接种活的RV16。所有10名患者均被感染，鼻腔冲洗和呼吸道症状显示鼻病毒已恢复正常。在整个研究过程中，基线FEV1值是稳定的。在急性RV病期间，呼吸道对组胺和豚草抗原的反应性显著增加(P分别为0.019和0.014)。在RV接种前，10名受试者中只有1名在抗原攻击后出现LAR。然而，在急性RV病期间，10名患者中有8名患者有LAR(与基线相比P<；0.0085)；LAR的发展与呼吸道反应性的变化和对抗原的即刻反应强度无关。因此，我们发现，RV呼吸道疾病不仅增强了呼吸道的反应性，而且也使过敏患者容易发生LARS，这可能是病毒诱导的支气管高反应性的一个重要因素。
Although viral upper respiratory infections (URIs) provoke wheezing in many asthma patients, the effect of these illnesses on the airway response to inhaled antigen is not established. The following study evaluated the effect of an experimental rhinovirus (RV) illness on airway reactivity and response to antigen in 10 adult ragweed allergic rhinitis patients. Preinfection studies included measurements of airway reactivity to histamine and ragweed antigen. Furthermore, the patients were also evaluated for late asthmatic reactions (LARs) to antigen (a 15% decrease in forced expiratory volume of the first second .apprx. 6 h after antigen challenge). 1 mo after baseline studies, the patients were intranasally inoculated with live RV16. All 10 patients were infected as evidenced by rhinovirus recovery in nasal washings and respiratory symptoms. Baseline FEV1 values were stable throughout the study. During the acute RV illness, there was a significant increase in airway reactivity to both histamine and ragweed antigen (P = 0.019 and 0.014, respectively). Before RV inoculation, only 1 of the 10 subjects had an LAR after antigen challenge. However, during the acute RV illness, 8 of 10 patients had an LAR (P < 0.0085 compared with baseline); the development of LARs was independent of changes in airway reactivity and the intensity of the immediate response to antigen. Therefore, we found that not only does a RV respiratory tract illness enhance airway reactivity, but it also predisposes the allergic patient to develop LARs, which may be an important factor in virus-induced bronchial hyperresponsiveness.