EFFECT OF CALCIFICATION ON INVIVO MECHANICAL RESPONSE OF RABBIT ARTERIES TO BALLOON DILATION
EFFECT OF CALCIFICATION ON INVIVO MECHANICAL RESPONSE OF RABBIT ARTERIES TO BALLOON DILATION
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DOI：
10.1161/01.cir.83.6.2083
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发表时间：
1991-06-01
期刊：
影响因子：
37.8
通讯作者：
DEMER, LL
中科院分区：
文献类型：
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作者：
DEMER, LL
背景在人类尸体和实验动物模型中，动脉粥样硬化与动脉壁扩张性的丧失有关，使其成为术语“动脉硬化”。”方法和结果。为了评估钙化对动脉扩张性的影响，在Watanabe遗传性高血压（WHHL）家兔体内扩张钙化动脉的过程中记录球囊压力和体积。钙化是由胆固醇、维生素D2和钙的膳食补充剂诱导的。在控制温度和球囊膨胀率的情况下，高频采集球囊压力、容积和时间信号。（Δ V（max）= 5.0 +/-3.5-μ l）和切除的非动脉粥样硬化的人冠状动脉中，并且在来自胆固醇喂养的兔的动脉粥样硬化中是小的（12.3 +/- 8 μ-l），即使高胆固醇饮食（611 +/- 347 mg/dl）使脂质水平显著升高。通过饮食胆固醇、维生素D2和钙补充剂，WHHL兔出现轻度高钙血症（15 +/- 1.9 mg/dl）、高胆固醇血症（1，100 +/- 633 mg/dl）、中度至显著主动脉钙化和高球囊扩张阻力（38 +/- 27），与血管成形术患者中观察到的结果相当。可以得出结论，实验诱导的钙化降低了兔主动脉在体内的扩张性，它产生的球囊扩张的塑性变形密切类似于在球囊血管成形术的人冠状动脉。这些发现表明钙化导致动脉硬化。
Background. Atherosclerosis has been associated with loss of artery wall distensibility in human cadavers and in experimental animal models, giving it the lay term "hardening of the arteries."Methods and Results. To assess the effect of calcification on arterial distensibility, balloon pressure and volume were recorded during dilation of calcified aortas in Watanabe heritable hyperlipidemic (WHHL) rabbits in vivo. Calcification was induced by dietary supplements of cholesterol, vitamin D2, and calcium. Balloon pressure, volume, and time signals were acquired at high frequency with controls for temperature and balloon inflation rate.Resistance to balloon dilation was minimal in control rabbit aortas (DELTA-V(max) = 5.0 +/- 3.5-mu-l) and in excised nonatherosclerotic human coronary arteries, and it was small in aortas from cholesterol-fed rabbits (12.3 +/- 8-mu-l), even when lipid levels were markedly elevated by a high cholesterol diet (611 +/- 347 mg/dl). With dietary cholesterol, vitamin D2, and calcium supplements, WHHL rabbits developed mild hypercalcemia (15 +/- 1.9 mg/dl), hypercholesterolemia (1,100 +/- 633 mg/dl), moderate-to-marked aortic calcification, and high resistance to balloon dilation (38 +/- 27) comparable to that seen in angioplasty patients.Conclusions. It is concluded that experimentally induced calcification decreases the distensibility of the rabbit aorta in vivo and that it yields to balloon dilation by plastic deformation closely resembling that seen in balloon angioplasty of human coronary arteries. These findings suggest that calcification contributes to arterial "hardening" associated with atherosclerosis.